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Gene Information
Gene symbol: PSEN1
Gene name: presenilin 1
HGNC ID: 9508
Synonyms: FAD, S182, PS1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | APOE | 1 hits |
| 2 | APP | 1 hits |
| 3 | BACE1 | 1 hits |
| 4 | INS | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17101827 | The mean age at onset of AD was significantly lower in FAD than in SAD, and a statistically significant dose effect of the APOE epsilon4 allele was present for age at onset in FAD (P = .001) but not in SAD. |
| 2 | 20819221 | In contrast, we detected little change in Alzheimer A? precursor protein expression, or BACE1 and Presenilin 1 levels. |
| 3 | 19046405 | Taken together, these data indicate that short-term WD is sufficient to selectively promote cerebral oxidative stress and metabolic disturbances in APP x PS1 knock-in mice, with increased oxidative stress preceding alterations in Abeta. |
| 4 | 21411544 | Insulin infusion significantly suppressed the expression of APP, presenilin-1, presenilin-2, and glycogen synthase kinase-3? in peripheral blood mononuclear cells. |
| 5 | 21538175 | The mechanism(s) behind this glucose intolerance in PSEN1 and APP/PSEN1 mice appeared to involve increased levels of brain retinol-binding protein 4 and basal phosphorylation of S6 ribosomal protein, and decreased insulin-stimulated phosphorylation of Akt/protein kinase B and extracellular signal-regulated kinase 1/2 in the brain. |