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Gene Information
Gene symbol: PTF1A
Gene name: pancreas specific transcription factor, 1a
HGNC ID: 23734
Synonyms: PTF1-p48, bHLHa29
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FOXA2 | 1 hits |
| 2 | INS | 1 hits |
| 3 | ONECUT1 | 1 hits |
| 4 | PDX1 | 1 hits |
| 5 | SOX9 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21855631 | Almost all cells in PDX1(+) clusters co-express FOXA2, HNF1ß, HNF6 and SOX9 proteins, and many cells also express CPA1, NKX6.1 and PTF1a. |
| 2 | 21497092 | We found that postembryonic antagonism of Ptf1a, a master regulator of pancreatic development and acinar cell fate specification, induced the expression of endocrine genes including insulin in the exocrine compartment. |
| 3 | 15331541 | In vitro treatment of embryonic pancreata with dexamethasone, a glucocorticoid agonist, induced a decrease of insulin-expressing cell numbers and a doubling of acinar cell area, indicating that glucocorticoids favored acinar differentiation; in line with this, expression of Pdx-1, Pax-6, and Nkx6.1 was downregulated, whereas the mRNA levels of Ptf1-p48 and Hes-1 were increased. |
| 4 | 15585742 | RT-PCR analysis showed that Pdx1-positive cells from day 8 cultures expressed the early endoderm markers Ptf1a, Foxa2, Hnf4alpha, Hnf1beta, and Hnf6, consistent with the notion that they corresponded to the early pancreatic endoderm present in the embryonic day 9.5 mouse embryo. |