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Gene Information
Gene symbol: PTK2
Gene name: PTK2 protein tyrosine kinase 2
HGNC ID: 9611
Synonyms: FAK, FADK, FAK1, PPP1R71
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCK | 1 hits |
| 2 | EPHB2 | 1 hits |
| 3 | INS | 1 hits |
| 4 | LYN | 1 hits |
| 5 | PPP1R13B | 1 hits |
| 6 | PTPN1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11809746 | This suggests that FAK and GSK-3beta form both a constitutive association and a transient complex upon insulin stimulation, the dissociation of which requires normal function and localization of FAK. |
| 2 | 15866871 | We show that down-regulation of PTP1B activity with small molecule inhibitors suppresses cell spreading and migration to fibronectin, increases Tyr(527) phosphorylation in Src, and decreases phosphorylation of FAK, p130(Cas), and ERK1/2. |
| 3 | 16713446 | CCK stimulated an association of Lyn with PKC-delta, Shc, p125(FAK) and PYK2 as well as with their autophosphorylated forms, but not with Cbl, p85, p130(CAS) or ERK 1/2. |
| 4 | 16713446 | CCK's activation of Lyn is likely an important mediator of its ability to cause tyrosine phosphorylation of numerous important cellular mediators such as p125(FAK), PYK2, PKC-delta and Shc, which play central roles in CCK's effects on acinar cell function. |