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Gene Information
Gene symbol: PTPN2
Gene name: protein tyrosine phosphatase, non-receptor type 2
HGNC ID: 9650
Synonyms: TCELLPTP, TC-PTP, TCPTP
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BCL2L11 | 1 hits |
| 2 | CASP3 | 1 hits |
| 3 | CYCS | 1 hits |
| 4 | INS | 1 hits |
| 5 | MAPK8 | 1 hits |
| 6 | PTPN1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15158797 | In general, the selectivity of the inhibitors for PTP1B was good compared to LAR, but modest when compared to TCPTP and CD45. |
| 2 | 16198645 | As well, TC-PTP has also been recently involved in insulin signaling in vitro. |
| 3 | 19238234 | These compounds exhibit good selectivity for PTP1B over most of phosphatases in selectivity panel such as SHP-2, LAR, CD45 and TCPTP found in literature. |
| 4 | 20380650 | PTP1B inhibitory activity and the inhibition mode were assayed with p-nitrophenyl phosphate as a substrate, and the selectivity of JTT-551 against other PTPs, including T-cell protein tyrosine phosphatase (TCPTP), CD45 protein tyrosine phosphatase (CD45) and leucocyte common antigen-related protein tyrosine phosphatase (LAR), was evaluated. |
| 5 | 20484139 | Insulin-induced IR-beta-subunit Y1162/Y1163 phosphorylation and PI3K/Akt signaling and IL-6-induced STAT3 phosphorylation were also enhanced in isolated Ptpn2+/- hepatocytes. |
| 6 | 20484139 | Liver TCPTP antagonises both insulin and STAT3 signaling pathways to regulate gluconeogenic gene expression and hepatic glucose output. |
| 7 | 21984578 | RESEARCH DESIGN AND METHODS Small interfering RNAs were used to inhibit PTPN2, STAT1, Bim, and Jun NH(2)-terminal kinase 1 (JNK1) expression. |
| 8 | 21984578 | PTPN2 silencing and exposure to type I and II IFNs induced BAX translocation to the mitochondria, cytochrome c release, and caspase 3 activation. |
| 9 | 21984578 | CONCLUSIONS The present findings suggest that local IFN production may interact with a genetic factor (PTPN2) to induce aberrant proapoptotic activity of the BH3-only protein Bim, resulting in increased ?-cell apoptosis via JNK activation and the intrinsic apoptotic pathway. |