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Gene Information

Gene symbol: PTPN22

Gene name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

HGNC ID: 9652

Synonyms: Lyp, Lyp1, Lyp2

Related Genes

#	Gene Symbol	Number of hits
1	CSK	1 hits
2	IL2RA	1 hits
3	MS	1 hits
4	SLEV1	1 hits

Related Sentences

#	PMID	Sentence
1	15934099	The aim of this study was to investigate associations of the missense SNP of PTPN22 in a number of autoimmune diseases in the UK population, including RA, juvenile idiopathic arthritis (JIA), psoriasis, psoriatic arthritis (PsA), and multiple sclerosis (MS), some of which have not been examined previously.
2	16185328	A single-nucleotide polymorphism (C1858T) causing an amino acid substitution (R620W) in the lymphoid protein tyrosine phosphatase gene PTPN22 has been implicated in type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, Graves' disease, juvenile idiopathic arthritis and Hashimoto's thyroiditis, thus revealing a general role for this gene in autoimmune disease.
3	20849903	Our goals were to study the proposed association of IL-2RA /CD25 with type 1 diabetes in the Belgian population over a broad age range, and to explore possible correlations with disease phenotypes, immune markers, HLA-DQ, INS, and PTPN22.
4	21044313	Importantly, an allelic R620W variant of LYP is strongly associated with multiple autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, and autoimmune thyroid disease.
5	15620463	One function of Lyp is downregulation of T-cell signaling through its interaction with the negative regulatory kinase C-terminal Src tyrosine kinase (Csk).