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Gene Information
Gene symbol: PTPN6
Gene name: protein tyrosine phosphatase, non-receptor type 6
HGNC ID: 9658
Synonyms: HCP, HCPH, PTP-1C, SHP-1, SHP1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | CD72 | 1 hits |
| 3 | INS | 1 hits |
| 4 | JAK2 | 1 hits |
| 5 | PKNOX1 | 1 hits |
| 6 | TCF7 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11279518 | The Tcf1 protein (also known as HNF-1alpha) also regulates transcription of the gene (Nr1h4) encoding the farnesoid X receptor-1 (Fxr-1), thereby leading to reduced expression of small heterodimer partner-1 (Shp-1) and repression of Cyp7a1, the rate-limiting enzyme in the classic bile acid biosynthesis pathway. |
| 2 | 17647198 | SHP-1 and SHP-2 modulate cellular signals that involve phosphatidylinositol 3-kinase, Akt, Janus kinase 2, signal transducer and activator of transcription proteins, mitogen-activating protein kinases, extracellular signal-related kinases, c-Jun-amino terminal kinases, and nuclear factor-kappaB. |
| 3 | 20864515 | Tyrosine phosphorylation of both insulin receptor (IR) and insulin receptor substrate (IRS)1/2 was significantly enhanced in Prep1(i/i) livers accompanied by a specific downregulation of the SYP and SHP1 tyrosine phosphatases. |
| 4 | 20864515 | Prep1 overexpression in HepG2 liver cells upregulated SYP and SHP1 and inhibited insulin-induced IR and IRS1/2 phosphorylation and was accompanied by reduced glycogen content. |
| 5 | 20864515 | Both Prep1 and Pbx1 bind SHP1 promoter at a site located between nucleotides -2,113 and -1,778. |
| 6 | 20864515 | SHP1, a known silencer of insulin signal, is a transcriptional target of Prep1. |
| 7 | 20864515 | In liver, transcriptional activation of SHP1 gene by Prep1 attenuates insulin signal transduction and reduces glucose storage. |
| 8 | 19067131 | Thus, CD72 interacts with SHP-1, an SH2-domain containing protein tyrosine phosphatase, a negative regulator of signaling, and Grb2, an adaptor protein associated with the Ras/MAPK pathway. |