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Gene Information
Gene symbol: PTPRH
Gene name: protein tyrosine phosphatase, receptor type, H
HGNC ID: 9672
Synonyms: SAP-1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | ILK | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12101188 | This effect of SAP-1 was dependent on cellular caspase activities and was preceded by inactivation of two serine-threonine protein kinases, Akt and integrin-linked kinase (ILK), both of which function downstream of phosphoinositide (PI) 3-kinase to promote cell survival. |
| 2 | 12101188 | Furthermore, expression of a dominant negative mutant of PI 3-kinase did not induce cell death as efficiently as did SAP-1, although this mutant inhibited Akt and ILK activities more effectively than did SAP-1. |
| 3 | 12101188 | These results suggest that SAP-1 induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. |