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Gene Information
Gene symbol: PVT1
Gene name: Pvt1 oncogene homolog (mouse)
HGNC ID: 9709
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | COL4A1 | 1 hits |
| 2 | FN1 | 1 hits |
| 3 | MMRN1 | 1 hits |
| 4 | SERPINE1 | 1 hits |
| 5 | TGFB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21526116 | We knocked-down PVT1 expression in mesangial cells using RNA interference, and analyzed RNA and protein levels of fibronectin 1 (FN1), collagen, type IV, alpha 1 (COL4A1), transforming growth factor beta 1 (TGFB1) and plasminogen activator inhibitor-1 (SERPINE1 or PAI-1) by qPCR and ELISA, respectively. |
| 2 | 21526116 | PVT1 expression was significantly upregulated by glucose treatment in human mesangial cells, as were levels of FN1, COL4A1, TGFB1, and PAI-1. |
| 3 | 21526116 | Importantly, PVT1 knockdown significantly reduced mRNA and protein levels of the major ECM proteins, FN1 and COL4A1, and two key regulators of ECM proteins, TGFB1 and PAI-1. |
| 4 | 21526116 | However, we observed a higher and more rapid reduction in levels of secreted FN1, COL4A1, and PAI-1 compared with TGFB1, suggesting that at least some of the PVT1 effects on ECM proteins may be independent of this cytokine. |
| 5 | 21526116 | These results indicate that PVT1 may mediate the development and progression of diabetic nephropathy through mechanisms involving ECM accumulation. |