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Gene Information
Gene symbol: RAB4A
Gene name: RAB4A, member RAS oncogene family
HGNC ID: 9781
Synonyms: HRES-1/RAB4
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | AKT2 | 1 hits |
| 3 | INS | 1 hits |
| 4 | SLC2A4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8037667 | Western-blot analysis of microsomal membranes with a panel of antisera against rab GTP-binding proteins indicated the presence of rab4A, with a molecular mass of 24 kDa, whereas rab1A, rab2 and rab6 were not observed. rab4A was barely detectable in GLUT4-enriched vesicles; however, insulin produced an extensive shift of rab4A from the cytosol and the microsomal fraction to the plasma membrane with a parallel increase in GLUT4. |
| 2 | 7575448 | In addition to the translocation of GLUT4, insulin was found to promote the movement of the small GTP-binding protein rab4A from the cytosol (decrease to 61 +/- 13% of control) to the plasma membrane (increase to 177 +/- 19% of control) in lean rats with no effect of the hormone on rab4A redistribution in the obese group. |
| 3 | 20728450 | Expression profiling of akt2(-/-) myocardium revealed that Rab4a, a GTPase involved in glucose transporter 4 translocation and ?-adrenergic receptor (?AR) recycling to the plasma membrane, was significantly induced. |
| 4 | 20728450 | Confirmatory analysis revealed up-regulation of Rab4a mRNA and protein in akt2(-/-) myocardium. |
| 5 | 20728450 | In cultured cardiomyocyte experiments, Rab4a was induced by pharmacological inhibition of Akt as well as by specific knockdown of Akt2 with siRNA. |