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Gene Information
Gene symbol: RARRES2
Gene name: retinoic acid receptor responder (tazarotene induced) 2
HGNC ID: 9868
Synonyms: TIG2, HP10433
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | AKT1 | 1 hits |
| 3 | CMKLR1 | 1 hits |
| 4 | CRP | 1 hits |
| 5 | INS | 1 hits |
| 6 | IRS1 | 1 hits |
| 7 | LEP | 1 hits |
| 8 | MAPK14 | 1 hits |
| 9 | PRKAA1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17635925 | Chemerin (RARRES2 or TIG2) is a recently discovered chemoattractant protein that serves as a ligand for the G protein-coupled receptor CMKLR1 (ChemR23 or DEZ) and has a role in adaptive and innate immunity. |
| 2 | 17635925 | Cultured 3T3-L1 adipocytes secrete chemerin protein, which triggers CMKLR1 signaling in adipocytes and other cell types and stimulates chemotaxis of CMKLR1-expressing cells. |
| 3 | 17635925 | We conclude that chemerin is a novel adipose-derived signaling molecule that regulates adipogenesis and adipocyte metabolism. |
| 4 | 17640997 | Gene expression of chemerin and its receptor, chemokine-like receptor 1 (CMKLR1), was significantly higher in adipose tissue of obese and type 2 diabetic P. obesus compared with lean, normoglycemic P. obesus. |
| 5 | 19552838 | Serum Chemerin is correlated with insulin level, body fat disposition and lipid metabolism which suggesting that it may play a role in the pathophysiology of obesity and metabolic syndrome. |
| 6 | 19720798 | Furthermore, higher chemerin release is associated with insulin resistance at the level of lipogenesis and insulin-induced antilipolysis in adipocytes. |
| 7 | 19720798 | Chemerin induces insulin resistance in human skeletal muscle cells at the level of insulin receptor substrate 1, Akt and glycogen synthase kinase 3 phosphorylation, and glucose uptake. |
| 8 | 19720798 | Furthermore, chemerin activates p38 mitogen-activated protein kinase, nuclear factor-kappaB, and extracellular signal-regulated kinase (ERK)-1/2. |
| 9 | 19558533 | Chemerin positively correlated with leptin, resistin and C-reactive protein (CRP). |
| 10 | 19558533 | In T2D, chemerin was similar in male and female patients and increased in patients with elevated CRP. |
| 11 | 20375212 | Chemerin is a new adipokine involved in in vitro adipogenesis and insulin resistance and associates with body mass index (BMI) in vivo. |
| 12 | 20002564 | Chemerin and vaspin are recently described adipocytokines with various suggested functions and potential to modulate inflammatory response and insulin resistance (IR). |
| 13 | 20724582 | Chemerin reduced insulin-stimulated Akt1 phosphorylation and activation of 5'AMP-activated protein kinase (AMPK) in the skeletal muscle, but had no effect on Akt phosphorylation and insulin-stimulated AMPK activation in the liver and gonadal adipose tissue. |
| 14 | 20724582 | Chemerin induces insulin resistance in the skeletal muscle in vivo. |
| 15 | 20601896 | Multiple regression analysis showed that waist circumference, diastolic blood pressure, 2-hour plasma insulin after glucose overload, and HbA1c were independently related factors influencing plasma chemerin levels. |
| 16 | 20601896 | The present work indicates the potential link of chemerin with the pathogenesis of insulin resistance, obesity, and metabolic syndrome. |
| 17 | 20424419 | Chemerin was recently introduced as a novel adipokine playing a crucial role in adipocyte differentiation and insulin signaling. |
| 18 | 21668495 | Omentin-1 and chemerin have been identified as interesting novel adipokines that may modulate insulin action. |