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Gene Information
Gene symbol: RBP1
Gene name: retinol binding protein 1, cellular
HGNC ID: 9919
Synonyms: CRABP-I, CRBP1, CRBP, RBPC, CRBPI
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | INS | 1 hits |
| 3 | PPARA | 1 hits |
| 4 | RARA | 1 hits |
| 5 | RXRA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 2555241 | Considered together, the presence of CRBP and CRABP in a beta-cell line and the increase in KCl-induced insulin release by retinol and retinoic acid are consistent with the idea that retinol has a functional role in insulin secretion and suggest a potential mechanism of action at the beta-cell level similar to that observed in other retinoid-responsive cells. |
| 2 | 19114589 | In adipocytes, the overexpression of CRBP1 enhanced (4- to 5-fold) the activity of promoters containing response elements for retinol-dependent nuclear receptors [retinoic acid receptor (RAR) and retinoid X receptor (RXR)] or peroxisome proliferator-activated receptors (PPAR). |
| 3 | 19114589 | CRBP1 overexpression also enhanced the promoter activity (by 470 +/- 40%) and expression/release of the anti-inflammatory and antiatherogenic adipokine adiponectin (cellular adiponectin by 196 +/- 24%, soluble adiponectin by 228 +/- 74%). |
| 4 | 19114589 | Significantly increased adiponectin secretion was also observed after ACE inhibitor treatment of human preadipocytes, an effect prevented by small interfering RNA against CRBP1. |
| 5 | 19114589 | In summary, ACE inhibitors affect adipocyte homeostasis via CRBP1 through the activation of RAR/RXR-PPAR signaling and up-regulation of adiponectin. |