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Gene Information
Gene symbol: REG3A
Gene name: regenerating islet-derived 3 alpha
HGNC ID: 8601
Synonyms: HIP, REG-III, REG3, PBCGF, PAP1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | EXTL3 | 1 hits |
| 3 | FOS | 1 hits |
| 4 | IAPP | 1 hits |
| 5 | IL6 | 1 hits |
| 6 | INS | 1 hits |
| 7 | LPIN1 | 1 hits |
| 8 | LPIN3 | 1 hits |
| 9 | NEUROD1 | 1 hits |
| 10 | NLRP2 | 1 hits |
| 11 | PDX1 | 1 hits |
| 12 | RP9 | 1 hits |
| 13 | STAT1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17054456 | Nevertheless, in a subset of patients with NIPHS, there exists some, as yet undefined, pancreatic humoral/paracrine factor(s) other than proinsulin, amylin, PDX-1, Nkx-6.1 and possibly glucagon-like peptide-1 (GLP-1) that are capable of inducing the INGAP gene and, if activated, will initiate ductal proliferation and islet neogenesis. |
| 2 | 17065390 | We also demonstrate for the first time that INGAP gene expression was significantly induced by treatment with interleukin (IL)-6 and further enhanced by a combination of IL-6 with dexamethazone and nicotinamide. |
| 3 | 17065390 | Additionally, our data suggest that the effect of IL-6 on INGAP expression is mediated via the JAK/STAT3 signaling pathway. |
| 4 | 19158046 | HIP enhanced EXTL3 translocation from the membrane to the nucleus, in support of a model whereby EXTL3 mediates HIP signaling for islet neogenesis. |
| 5 | 19343564 | Our results suggest that Reg3alpha stimulates beta-cell replication, by activating Akt kinase and increasing the levels of cyclin D1/CDK4. |
| 6 | 19799857 | Compared to non-diabetic littermates (ZDF-fa/+), left ventricular PAP(1) activity was 29% lower in diabetic ZDF-fa/fa rats. |
| 7 | 19799857 | PAP(1) activity was highly related with cardiac lipin-1 and lipin-3 mRNA expression in ZDF rats (r=0.99 and 0.96). |
| 8 | 19799857 | Consistent with the findings in experimental animals, human atrial tissue displayed PAP(1) activity that was 33% lower in those having diabetes than in non-diabetic controls. |
| 9 | 19799857 | Insulin therapy increased both PAP(1) activity and lipin mRNA expression in diabetic patients. |
| 10 | 16522740 | Analysis of the INGAP promoter suggested that candidate regulators of INGAP expression include the transcription factors PDX-1, NeuroD, PAN-1, STAT and AP-1. |
| 11 | 19770784 | Independently, Pdx-1, Pan-1, and NeuroD bind to the INGAP promoter as revealed by electrophoresis mobility shift assay studies. |
| 12 | 19770784 | These data reveal a dynamic interaction between Pdx-1, NeuroD, and Pan-1 for the regulation of INGAP promoter activity. |