Ignet

Gene Information

Gene symbol: RETN

Gene name: resistin

HGNC ID: 20389

Synonyms: FIZZ3, ADSF, RETN1

Related Genes

#	Gene Symbol	Number of hits
1	ADIPOQ	1 hits
2	AKT1	1 hits
3	ALB	1 hits
4	ANGPTL4	1 hits
5	CCL2	1 hits
6	CD14	1 hits
7	CD36	1 hits
8	CD4	1 hits
9	CDC42	1 hits
10	CNBP	1 hits
11	CNTF	1 hits
12	CREB1	1 hits
13	CRP	1 hits
14	CX3CL1	1 hits
15	EP300	1 hits
16	EPO	1 hits
17	ESAM	1 hits
18	F10	1 hits
19	FAS	1 hits
20	FOS	1 hits
21	GCG	1 hits
22	GHRL	1 hits
23	ICAM1	1 hits
24	IGF1	1 hits
25	IL10	1 hits
26	IL1B	1 hits
27	IL6	1 hits
28	INS	1 hits
29	INSR	1 hits
30	IRS1	1 hits
31	ITLN1	1 hits
32	LEP	1 hits
33	LEPR	1 hits
34	MAP2K1	1 hits
35	MAPK8	1 hits
36	NAMPT	1 hits
37	NFKB1	1 hits
38	NOX5	1 hits
39	NPY	1 hits
40	PPARA	1 hits
41	PPARG	1 hits
42	PRKAA1	1 hits
43	PYY	1 hits
44	RAC1	1 hits
45	RB1	1 hits
46	REN	1 hits
47	RHOA	1 hits
48	RPS6KB1	1 hits
49	SCD	1 hits
50	SERPINE1	1 hits
51	SLC2A4	1 hits
52	SNAI1	1 hits
53	SOD1	1 hits
54	SP1	1 hits
55	SP3	1 hits
56	SREBF1	1 hits
57	STN	1 hits
58	TIMP1	1 hits
59	TNF	1 hits
60	TNNI3	1 hits
61	UBASH3B	1 hits
62	UCP2	1 hits
63	VCAM1	1 hits

Related Sentences

#	PMID	Sentence
1	21914779	Infection increased macrophage chemoattractant protein-1, visfatin, and IL-6 secretion, whereas resistin and adiponectin were decreased.
2	11201732	Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action.
3	11373275	Elevated levels of the hormone resistin, which is secreted by fat cells, are proposed to cause insulin resistance and to serve as a link between obesity and type 2 diabetes.
4	11809189	Resistin, an adipocyte-derived cytokine, causes insulin resistance and glucose intolerance in mice.
5	11901161	C/EBPalpha binding was associated with the recruitment of coactivators p300 and CREB-binding protein and a dramatic increase in histone acetylation in the vicinity of the resistin promoter.
6	11901161	The antidiabetic thiazolidinedione (TZD) drug rosiglitazone reduced resistin expression with an ED(50) similar to its K(d) for binding to peroxisome proliferator activated receptor gamma (PPARgamma).
7	11901161	Nevertheless, rosiglitazone treatment selectively decreased histone acetylation at the resistin promoter without a change in occupation by C/EBPalpha, CREB-binding protein, or p300.
8	12660880	Resistin treatment impaired glucose tolerance and insulin action.
9	12684710	However, little is known about the effects of neuropeptide Y (NPY) on resistin gene expression in white adipose tissue (WAT).
10	12684710	Administered NPY (1 nmol/mouse) significantly increased resistin mRNA expression in WAT by 72% compared with artificial cerebrospinal fluid treated controls.
11	12814870	The protein hormone, resistin, secreted specifically by the adipose tissues, is found to antagonize insulin action upon glucose uptake and may serve as an important role between human obesity and insulin resistance.
12	14521723	Correlation analysis demonstrated that fasting resistin level was not correlated with sex, BMI, leptin, and blood pressure, but positively correlated with QUICKI (r = 0.30, P < 0.01) and negatively correlated with blood glucose (r = -0.21, P < 0.05).
13	14550293	Therefore, caution should be exercised in interpreting resistin as a link between obesity and insulin resistance in humans.
14	14962997	Resistin is an adipose-derived hormone that has been proposed as a link among obesity, insulin resistance, and diabetes.
15	14962997	In the present study we investigated the effects of leptin administration on adipose resistin expression in insulin-resistant and obese ob/ob mice.
16	14962997	Leptin administration in ob/ob mice resulted in improvement of insulin sensitivity concomitant with a decrease in resistin gene expression.
17	14962997	The lack of effect of leptin on resistin in db/db mice indicated that the leptin inhibitory action on resistin expression requires the long leptin receptor isoform.
18	14962997	In addition, we demonstrated that the effect of leptin on resistin expression was centrally mediated.
19	14962997	In conclusion, our results demonstrate that leptin decreases resistin expression and suggest that resistin may influence glucose homeostasis.
20	15024400	Taken collectively, plasma resistin concentration, before and after PIO treatment, correlated positively with hepatic fat content (r=0.66, P<0.001) and EGP during the insulin clamp (r=0.41, P<0.05).
21	15024400	However, the plasma resistin concentration did not correlate with whole body glucose disposal (Rd) during the insulin clamp either before (r=-0.18, P=NS) or after (r=-0.13, P=NS) PIO treatment.
22	15024400	The decrease in plasma resistin is positively correlated with the decrease in hepatic fat content and improvement in hepatic insulin sensitivity.
23	15155948	Infusion of a resistin mutant, lacking the intertrimer disulfide bonds, in pancreatic-insulin clamp studies reveals substantially more potent effects on hepatic insulin sensitivity than those observed with wild-type resistin.
24	15451915	We conclude that adiponectin is significantly associated with inflammatory markers, in part, through an underlying association with obesity, whereas resistin's associations with inflammatory markers appear to be independent of BMI.
25	15578112	Induction of resistin was attenuated by drugs with dual insulin-sensitizing and anti-inflammatory properties that converge on NF-kappaB.
26	15578112	Moreover, in patients with type 2 diabetes, serum resistin levels are correlated with levels of soluble tumor necrosis factor alpha receptor, an inflammatory marker linked to obesity, insulin resistance, and atherosclerosis.
27	15522996	Resistin is an adipocyte-secreted hormone proposed to link obesity with insulin resistance and diabetes, but no previous study has performed a joint quantitative evaluation of white adipose tissue (WAT) resistin mRNA expression and serum levels in relation to insulinemia and glycemia in mice.
28	15522996	We also studied whether treatment with the weight-reducing and insulin-sensitizing compounds, MTII, an alpha-melanocyte-stimulating hormone analog, or CNTF(Ax15), a ciliary neurotrophic factor analog, alters resistin mRNA expression and/or circulating levels in lean and DIO C57BL/6J mice.
29	15522996	In addition, serum resistin levels, but not resistin mRNA expression levels, are correlated with body weight, and neither resistin mRNA expression nor serum resistin levels are correlated with serum insulin or glucose levels.
30	15585589	Resistin (Rstn) is known as an adipocyte-specific secretory factor that can cause insulin resistance and decrease adipocyte differentiation.
31	15585589	This study was designed to examine the influence and the signaling of IGF-I on Rstn gene expression and protein secretion by 3T3-L1 adipocytes.
32	15585589	We found that IGF-I suppressed Rstn mRNA expression and protein release in dose- and time-dependent manners.
33	15585589	Pretreatment with IGF-I receptor (IGF-IR) antibody blocked IGF-I-altered IGF-IR activity and Rstn mRNA levels.
34	15585589	These data demonstrate that IGF-I downregulates Rstn gene expression via IGF-IR-dependent and MEK1-, p38 MAPK-, and phosphoinositide 3-kinase-independent pathways and likely modifies the distribution of Rstn protein between the intracellular and extracellular compartments via a p38 MAPK-dependent pathway.
35	15585589	Decreases in Rstn production and secretion induced by IGF-I may be related to the mechanism by which IGF-I modulates body weight and diabetes in animals.
36	15864531	Resistin is an adipokine that might link obesity and insulin resistance.
37	15864531	Sp1 and stimulatory protein 3 (Sp3) specifically bound to the region around -420G of the human resistin gene.
38	15864531	Mithramycin A, an inhibitor of DNA binding of Sp1, reduced the effect of high glucose on transcription induction of the resistin gene in adipocytes.
39	15864531	These results suggest that Sp1 is an important factor regulating transcription of human resistin gene.
40	15864531	A common polymorphism of the human resistin promoter, -420C >G, is critical for the binding of Sp1 and modulates the transcriptional activity of the resistin gene by changing the binding ability of Sp1.
41	15952917	Among those, adiponectin, visfatin and omentin appear as insulin-sensitising adipocytokines, whereas TNF-alpha, IL-6 and resistin induce insulin resistance.
42	15928242	Resistin appears to be not the main link between obesity and insulin resistance in children and adolescents but because of its association with Tanner stage, it may be related to the maturation of children during pubertal development.
43	15998471	The use of regression analysis also determined that serum resistin correlated with CRP levels (p = 0.04, R2 0.045).
44	16080635	It is suggested that circulating resistin levels are not associated with obesity or insulin resistance in humans.
45	16087164	Resistin, secreted from adipocytes, causes insulin resistance in rodents.
46	16173945	Both resistin and ghrelin produced modest but significant increases in VCAM-1 expression (110 +/- 4 and 117 +/- 13% compared with controls, respectively; both P
47	16173945	Pathophysiologically relevant concentrations of ghrelin and resistin, within the range of concentrations exhibited by patients with anorexia nervosa or the Prader-Willi syndrome and type 2 diabetes, respectively, increase endothelial cell adhesion molecule expression, possibly contributing to increased atherosclerosis risk in such subjects.
48	16306372	Diet-induced whole-body insulin resistance was associated with increased circulating levels of resistin and leptin but unaltered adiponectin levels.
49	16313475	Resistin, a peptide hormone produced by adipocytes, has been associated with diabetes mellitus type 2 (DM-2) in some rodent models.
50	16313475	Some, but not all studies have found associations between polymorphisms in the resistin gene with DM-2.
51	16313475	Recently a 3'-untranslated region +62G-->A polymorphism of the resistin gene has been associated with decreased risk for DM-2 and for hypertension in diabetics in a Chinese population.
52	16313475	In conclusion, the present data suggest that in a German Caucasian population the +62G-->A polymorphism of the resistin gene is associated with hypertension but not with DM-2.
53	16493877	Resistin and TNF-alpha positively correlated with each other, insulin, HOMA, and negatively with ghrelin.
54	16234302	In contrast, adiponectin was decreased (4.3 +/- 2.5 vs. 30.8 +/- 10.3 microg/ml, P < 0.001), whereas plasma resistin level did not differ between the groups.
55	16367888	Resistin 1 microm significantly reduced maximum insulin-stimulated 2-deoxyglucose uptake in L6 cells from 634 to 383% (relative to 100% for control, p < 0.001), and co-administration of rosiglitazone had no effect on resistin-induced insulin resistance.
56	16367888	In the absence of insulin, however, resistin increased glucose uptake dose-dependently (e.g., 1.75-fold at 5 microm, p < 0.001) via a mitogen-activated protein kinase-dependent pathway.
57	16367888	These results demonstrate that various glucose-lowering therapies and oleic acid reduce resistin gene expression in isolated adipocytes, and that resistin impairs insulin-stimulated glucose uptake in skeletal muscle-derived cells.
58	16159906	Resistin (Rstn) is known as an adipocyte-specific secretory hormone that can cause insulin resistance and decrease adipocyte differentiation.
59	16341686	Treatment of L6 rat skeletal muscle cells with recombinant resistin (50 nmol/l, 0-24 h) reduced levels of basal and insulin-stimulated 2-deoxyglucose uptake and decreased insulin-stimulated GLUT4myc content at the cell surface, with no alteration in the production of GLUT4 or GLUT1.
60	16341686	Insulin-stimulated oxidation of glucose via the Krebs cycle was reduced by resistin, whereas lactate production was unaltered.
61	16341686	Our data show that resistin regulates the function of IRS-1 and Akt1 and decreases GLUT4 translocation and glucose uptake in response to insulin.
62	16395259	In the present study, we explore the role of decreased renal function and a genetic polymorphism on the recently discovered protein resistin, apparently able to inhibit hepatic insulin action in mice.
63	16395259	However, in a multiple regression model, resistin, as well as all the measured markers of inflammation, was only associated with insulin resistance if GFR was not taken into account.
64	16625816	While in rodents resistin appears to have an important role in the development of liver insulin resistance, its role in humans is less clear, and it is probably involved in the regulation of inflammatory processes rather than in insulin sensitivity.
65	16876120	These results suggest that PPARgamma activation represses the expression of the resistin gene by modulating Sp1 activity.
66	17048191	The result suggests that plasma resistin has a role in linking central obesity and obesity-related insulin resistance to type II diabetes mellitus.
67	17059749	GLP-1 and PYY response to food ingestion were enhanced; fasting ghrelin and resistin were significantly reduced (P<0.05).
68	17065346	Nevertheless, resistin deficiency improved glucose tolerance and insulin sensitivity in these severely obese mice, largely by enhancing insulin-mediated glucose disposal in muscle and adipose tissue.
69	17065346	In contrast, in C57BL/6J mice with diet-induced obesity but wild-type leptin alleles, resistin deficiency reduced hepatic glucose production and increased peripheral glucose uptake.
70	16895955	We measured serum concentrations and sc and epicardial adipose tissue mRNA expression of IL-6, monocyte chemoattractant protein-1 (MCP-1), TNF-alpha, leptin, resistin, and adiponectin and sc and epicardial adipose tissue mRNA expression of CD14, CD45, and CD68.
71	16895955	Resistin levels peaked 4-fold 24 h after surgery, but adiponectin levels were not significantly affected.
72	17597619	This study investigated the effects of resistin on insulin secretion, insulin receptor expression and cell viability in pancreatic beta-cells.
73	17597619	BTC-6 or BRIN-BD11 cells were treated for 24h with resistin, and insulin receptor expression, insulin secretion and cell viability were measured.
74	17640666	In nondiabetic patients, there were significant increases compared with preoperative levels for adiponectin, resistin, and tumor necrosis factor-alpha; leptin was significantly decreased while CRP was unchanged.
75	17785630	Resistin, a recently discovered proinflammatory cytokine, has been variably associated with insulin resistance, inflammation, and renal dysfunction.
76	17785630	Higher plasma resistin levels were associated with a higher urine albumin:creatinine ratio in black subjects with diabetes (P<0.0001) and non-Hispanic white subjects with diabetes (P=0.032), independent of coronary heart disease risk factors, hypertension medication use, and statin use; the association remained significant after additional adjustment for homeostasis model assessment for insulin resistance and C-reactive protein.
77	17785630	In adults with hypertension, higher circulating resistin levels were associated with a lower estimated glomerular filtration rate and with increased urine albumin:creatinine ratio in the presence of concomitant diabetes.
78	17893258	The expressions of both resistin and adiponectin in s.c. adipose tissue are stimulated by acute hyperinsulinaemia, whereas losartan attenuates their insulin-stimulated expressions.
79	17184146	We conclude that administration of PPAR-alpha agonist fenofibrate for three months did not significantly affect insulin sensitivity or resistin and adiponectin concentrations in obese subjects with type 2 diabetes mellitus.
80	17952831	In rodents, resistin is produced by adipose tissue, and is a significant regulator of glucose metabolism and insulin sensitivity.
81	17178123	Adiponectin and resistin are proteins that affect insulin resistance and atherosclerosis significantly.
82	17936398	Resistin was initially identified as a protein, secreted by adipocytes, which inhibits insulin action and adipose differentiation.
83	18080721	Fasting ghrelin and resistin were significantly reduced (P < 0.05); GLP-1 and PYY response to food ingestion was enhanced (P < 0.05).
84	18180399	In vitro gene expression analysis in human coronary endothelial cells revealed that resistin induced fatty acid binding protein, a key molecule of insulin resistance, diabetes, and atherosclerosis.
85	18324929	It was accompanied by lower circulating resistin and plasminogen activator inhibitor-1 levels rapidly increased levels of circulating total and high molecular weight adiponectin as well as adiponectin and adipocyte fatty acid-binding protein (aP2) mRNA expression in the adipose tissue.
86	18328350	In stepwise regression analysis, white blood cell count (P < .001) and MCP-1 concentrations (P = .002) were significantly associated with resistin concentrations, independent of hs-CRP, sex, body mass index, presence of the metabolic syndrome, and high-density lipoprotein cholesterol.
87	18328350	Data from our cross-sectional study demonstrate that plasma resistin concentrations are associated with circulating chemokine markers of inflammation, namely, MCP-1, and white blood cell count in nondiabetic adults without CVD.
88	17614271	After 12 weeks, weight, body mass index, waist circumference, hip circumference, waist-to-hip ratio, total body fat, total cholesterol, triglyceride, tumor necrosis factor alpha (TNF-alpha), IL-6, resistin and leptin had significantly decreased, while adiponectin and IL-10 had significantly increased.
89	18081734	Resistin, secreted from adipocytes, causes insulin resistance in rodents.
90	18410550	On Spearman univariate correlation analysis, visfatin was significantly associated with resistin (r = 0.30, P = 0.0011), but not with any other anthropometric or metabolic variables, including adiponectin multimers.
91	19125180	The corresponding plasma resistin levels were slightly, but not significantly, increased in DM2 women (P = .051), and overall, they correlated significantly with BMI (r = 0.406, P = .010) and waist circumference (r = 0.516, P = .003), but not with fasting insulin levels or HOMA-IR.
92	19125180	Resistin mRNA expression is increased in PBMC from DM2 women, together with increased expression of the inflammatory cytokines IL-1beta, TNF-alpha, and IL-6, independent of obesity.
93	19156184	After Santoro II operation an adaptation of the gastric chamber size to hypercaloric diet and it removes the sources of ghrelin and aims at moderate restriction with early saciety by distention , omentectomy removes the sources of plasminogen activator inhibitor -1 (PAI-1) and resistin production, enterectomy leads more nutrients to the distal bowel and raising the levels of glucagon-like peptide -1 (GLP-1) , Peptide YY (PYY) and oxintomodulina (OXM) with desirable metabolic consequences.
94	19126543	Resistin antagonizes insulin action in mouse, making it a potential therapeutic target for treating metabolic diseases such as diabetes.
95	19126543	To better understand how mouse resistin gene (Retn) expression is restricted to fat tissue, we identified an adipocyte-specific enhancer located approximately 8.8-kb upstream of the transcription start site.
96	19126543	Taken together, the data suggest that a composite enhancer binding both PPARgamma and C/EBP factors confers adipocyte-specific expression to Retn in mouse, and its absence from the human gene may explain the lack of adipocyte expression in humans.
97	19221061	Elevated plasma insulin and resistin levels were significantly decreased by cilostazol, and decreased adiponectin mRNA expression was elevated along with increased plasma adiponectin.
98	19223612	VAT, SAT, pericardial fat, and intrathoracic fat were negatively correlated with adiponectin (r = -0.19 to -0.34, P < 0.001 [women]; r = -0.15 to -0.26, P < 0.01 [men] except SAT) and positively correlated with resistin (r = 0.16-0.21, P < 0.001 [women]; r = 0.11-0.14, P < 0.05 [men] except VAT).
99	18672341	Liver glycogen metabolism plays an essential role in maintaining glucose homeostasis, we investigated the effect of resistin on liver glycogen metabolism and attempted to identify its role in initiating insulin resistance and type 2 diabetes.
100	18672341	Hepatocytes exposed to resistin, but only in the presence of insulin, show a decrease in insulin-stimulated glycogen content.
101	18672341	These results strongly suggest that resistin effects glycogen metabolism at the protein level, and resistin is highly associated with insulin resistance and type 2 diabetes and is a candidate for the prevention and treatment of type 2 diabetes.
102	18839335	Resistin, an adipokine-linked obesity with type 2 diabetes, impairs glucose-stimulated insulin secretion (GSIS) in beta-cells.
103	18839335	Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) protected resistin-mediated cytotoxicity in RINm5F.
104	18839335	The molecular mechanism of TIMP-1 inhibition of resistin-mediated cytotoxicity appeared to involve Akt phosphorylation and activation of IkB-alpha phosphorylation.
105	18839335	Resistin treatment suppressed Akt phosphorylation and activated IkB-alpha phosphorylation, which could be attenuated by TIMP-1.
106	19298540	Importantly, inhibition of AMPK by 2 h pretreatment of cells with 20 micromol/L compound C completely abolished the CrPic-induced suppression of resistin secretion. 4.
107	19298540	In conclusion, the data suggest that CrPic inhibits resistin secretion via activation of AMPK in normal and insulin-resistant 3T3-L1 adipocytes.
108	19454585	Exposure of human AT and liver tissue in culture to LPS did not alter resistin concentration; however, concentrations of IL-1beta, IL-6, and TNFalpha were significantly increased in these tissues.
109	19922611	Resistin, secreted from adipocytes, causes insulin resistance in mice.
110	19940327	Adipose tissue produces multiple cytokines(TNF-alpha, IL-6, PAI-1, CRP, angiotensinogen, leptin, adiponectin, visfatin, apelin, resistin)which decrease insulin sensitivity and induce inflammatory processes, endothelial dysfunction,and atherosclerosis.
111	19684036	Resistin stimulated CD4-positive cell chemotaxis in a concentration-dependent manner with a maximal induction of 2.25 +/- 0.54 at 100 ng/mL (P < 0.05, n = 7).
112	19684036	Biochemical analysis showed that resistin induces phosphorylation of Src and PI 3-K activation in human CD4-positive cells.
113	19684036	In addition, resistin activates RhoA, Rac-1, and Cdc42 in these cells as shown by affinity precipitation experiments.
114	19727657	Multiple linear regression analysis with adjustment for age and sex also showed that the plasma resistin level was significantly associated with serum concentrations of HDL-cholesterol, triacylglycerol and insulin, as well as with BMI.
115	19727657	In addition, plasma resistin level was associated with dyslipidaemia, serum insulin concentration and obesity.
116	20034466	The results showed that in HEC (i) resistin increased P-selectin expression; (ii) HG up-regulated Fk expression; (iii) P-selectin and fractalkine were functional increasing monocyte adhesion to activated cells.
117	20034466	Co-stimulation with resistin and HG increased P-selectin and fractalkine mRNA and protein and induced monocyte adhesion, generated an increase in NADPH oxidase activity and of the intracellular reactive oxygen species and activated the NF-kB and AP-1 transcription factors at similar values as those of each activator.
118	19699280	Furthermore, the results of quantitative RT-PCR analysis showed that emodin significantly elevated the mRNA expression level of PPARgamma and regulated the mRNA expressions of LPL, FAT/CD36, resistin and FABPs (ap2) in liver and adipocyte tissues.
119	20435848	Three antioxidants, seleno-L-methionine, ginsenoside Rb1, and MnTBAP (superoxide dismutase mimetic), effectively blocked resistin-induced eNOS downregulation.
120	20435848	Thus resistin directly induces eNOS downregulation through overproduction of ROS and activation of p38 and JNK in HCAECs.
121	20378819	In a subset analysis of 362 women who also had measurements of inflammatory and endothelial biomarkers, plasma resistin levels significantly correlated with IL-6, soluble TNF receptor 2, intercellular adhesion molecule 1, vascular adhesion molecule 1, and E-selectin after controlling for age and body mass index.
122	20121885	Additionally, fasting plasma glucose, insulin and homeostatis model assessment of insulin resistance (HOMA-IR) significantly decreased while adiponectin increased over threefold [9.7 (3.7-17.7) vs. 38.0 (19.3-42.4) microg/ml] without any changes in resistin.
123	20472602	The significant findings were that (a) fiaf gene expression was elevated two- to fourfold in visceral and subcutaneous fat from ob/ob mice, compared with lean controls; (b) the increase in fiaf mRNA in subcutaneous, but not visceral, fat from ob/ob mice was returned to lean control levels following 2 weeks of valsartan treatment; (c) fiaf expression was reduced in the hypothalamus, but not in the cortex or pituitary, of ob/ob mice; (d) rstn expression was greatly reduced in visceral fat from ob/ob mice, compared with lean controls, but this was unaffected by valsartan; and (e) rstn expression was unchanged in all other tissues from ob/ob mice, with or without valsartan treatment.
124	20819535	To evaluate the association between the four adipokines, adiponectin, leptin, resistin and tumor necrosis factor-alpha (TNF-alpha) with insulin sensitivity, we used a hyperinsulinemic euglycemic clamp to test insulin sensitivity in Chinese patients with obesity and type 1 or type 2 diabetes mellitus versus controls.
125	19211226	Total cholesterol, low-density lipoprotein cholesterol, tumor necrosis factor-?, and resistin levels are elevated in patients with visfatin levels above the median value.
126	20699433	Insulin did not affect TNF-?, MCP-1, IL-6, LBP, resistin, and HMG-B1 increases induced by the LPS.
127	20300528	Resistin, secreted from adipocytes, causes insulin resistance in mice.
128	21159034	To investigate changes in maternal serum resistin levels during pregnancy and postpartum and clarify their relationship to insulin resistance.
129	21050256	Resistin levels were significantly higher in LS, where RAAS activity was high, when compared with HS balance, where RAAS activity was suppressed (6.36 vs 5.86 ?g/l, P < 0.0001); however, resistin concentrations were not associated with plasma renin activity or serum aldosterone on either diet. 25(OH)D levels were positively and independently associated with resistin in both dietary conditions (HS: ?=0.400, P-trend=0.027; LS: ?=0.540, P-trend=0.014).
130	21251282	Adiponectin and resistin are adipokines which modulate insulin action, energy, glucose and lipid homeostasis.
131	20827661	Moreover, serum resistin was not influenced by insulin resistance in either group examined.
132	20532833	Fasting serum was assayed for adiponectin, resistin, glucose, M30, M65, Tissue inhibitor of metalloproteinases-1 (Timp-1), ProCollagen 3 N-terminal peptide (PIIINP), and hyaluronic acid (HA).
133	15517149	Our results add to growing evidence that resistin is associated with variation in weight, fat distribution and insulin resistance.
134	21442412	In addition, curcumin downregulates the inflammatory cytokines, resistin and leptin, and upregulates adiponectin as well as other associated proteins.
135	21282361	Although adipocyte-derived murine resistin links insulin resistance to obesity, the role of human resistin, predominantly expressed in mononuclear cells and induced by inflammatory signals, remains unclear.
136	21282361	Thus, human resistin may link insulin resistance to inflammatory diseases such as obesity, type 2 diabetes, and atherosclerosis.
137	21262584	Adipocytokines such as tumor necrosis factor-alpha (TNF-?), C-reactive protein (CRP), adiponectin, leptin, resistin along with peroxisome proliferator activated receptor-? (PPAR-?) are important mediators in glucose homeostasis in association with CD36 and can be used as markers for T2DM and atherosclerosis.
138	15983036	Murine resistin reduced insulin-stimulated glucose uptake, establishing the heart as a resistin target tissue.
139	15983036	Notably, human resistin also impaired insulin action in mouse cardiomyocytes, providing the first evidence that human and mouse resistin homologs have similar functions.
140	15983036	Remarkably, unlike native resistin, monomeric C26A resistin had no effect on basal or insulin-stimulated glucose uptake in mouse cardiomyocytes.
141	18492747	The prevalence of insulin resistance increased with decreasing tertiles of adiponectin (from 10.9% in the third to 42.5% in the first tertile; P < 0.0001) and increasing tertiles of resistin (from 19.3 to 30.9%; P < 0.0001) and TNFalpha (from 18.8 to 32.0%; P < 0.0001).
142	19846171	Tumor necrosis factor alpha receptor 2 was still associated to HOMA-IR after adding adiponectin, resistin, and triglycerides (individually and simultaneously).
143	21205225	The MSG increased mRNA expression of interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF?), resistin and leptin, but adiponectin did not exhibit any changes.
144	21181202	Downregulation of resistin and leptin gene expression after bariatric surgery may play a role in normalizing obesity-associated insulin resistance.
145	18710472	Resistin causes insulin resistance and diabetes in mice whereas in humans it is linked to inflammation and atherosclerosis.
146	21285283	These results suggest that with increasing age autocrine effects of resistin in fat tissue may predispose to diabetes in part by impairing insulin action in adipose tissue.
147	21520070	Furthermore, resistin increased the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) by HUVECs and these effects were also p38MAPK-dependent.
148	21520070	Resistin-induced monocyte adhesion was also blocked by monoclonal antibodies against ICAM-1 and VCAM-1.
149	21520070	Taken together, these results show that resistin increases both the expression of ICAM-1 and VCAM-1 by endothelial cells and monocyte adhesion to HUVECs via p38MAPK-dependent pathways.
150	21694775	Additional in vitro analysis on adipokines regulating visfatin showed that only Abd Sc adipocytes treated with recombinant human (rh)IL-6 increased visfatin protein (*p<0.05), whilst rh visfatin treatment, itself, had no influence on TNF-?, IL-6 or resistin secretion from Sc adipocytes.
151	21694920	Fatty acid accumulation and resistin inhibit insulin and adiponectin.
152	21478152	Resistin has been suggested to be involved in the development of diabetes and insulin resistance.
153	21478152	Overexpression of resistin using adenoviral vector in neonatal rat ventricular myocytes was associated with inhibition of AMP-activated protein kinase (AMPK) activity, activation of tuberous sclerosis complex 2/mammalian target of rapamycin (mTOR) pathway, and increased cell size, [(3)H]leucine incorporation (i.e. protein synthesis) and mRNA expression of the hypertrophic marker genes, atrial natriuretic factor, brain natriuretic peptide, and ?-myosin heavy chain.
154	21478152	Resistin also stimulated the activation of p70(S6K), a downstream kinase target of mTOR, and increased phosphorylation of the IRS1 serine 636/639 residues, whereas treatment with rapamycin reduced the phosphorylation of these residues.
155	21478152	These data demonstrate that resistin induces cardiac hypertrophy and myocardial insulin resistance, possibly via the AMPK/mTOR/p70(S6K) and apoptosis signal-regulating kinase 1/JNK/IRS1 pathways.
156	16203173	Obesity resulting from excess nutrient intake can also cause insulin resistance by an increase in the production of agents that impair insulin action such as TNFalpha and resistin and a decrease in the production of an insulin sensitizing compound adiponectin.
157	21778676	EPO resistance is associated with low body mass index (BMI) (coefficient ? =-0.393, p = 0.002) and with high serum resistin levels (coefficient ? = 0.332, p = 0.018).
158	21676224	We postulated that CPAP will decrease IR, ghrelin and resistin and increase adiponectin levels in this setting.
159	21676224	Fasting ghrelin decreased significantly while leptin, adiponectin and resistin remained unchanged.
160	21808585	Resistin, another protein secreted by the adipose tissue, derived its name due to its involvement in the development of insulin resistance.
161	21586564	Acutely administered resistin increased lumbar SNA but decreased BAT SNA.
162	21447495	In group 2, serum resistin was positively correlated with serum troponin I and triglycerides (r=0.59, p<0.05, and r=0.47, p<0.05, respectively), but was negatively correlated with high density lipoprotein cholesterol (r=-0.46, p<0.05).
163	21447495	However, in this group, serum resistin was not correlated with age, gender, body mass index (BMI), total cholesterol, FBG, insulin, CK, LDH, and the calculated homeostasis model for insulin resistance (HOMA-IR) (p>0.05).
164	21774832	Furthermore, palmitoleic acid down-regulated mRNA expressions of proinflammatory adipocytokine genes (TNF? and resistin) in white adipose tissue and lipogenic genes (SREBP-1, FAS, and SCD-1) in liver.
165	21453187	In the patients with arthritis and MetS, resistin correlated positively with IL-6 (Pearson's r = 0.5, p = 0.03).
166	21750415	An immunofluorescence technique was used to examine the expression of resistin and its co-localization with insulin and glucagon in pancreatic islet cells.
167	21750415	Resistin co-localized with insulin but not glucagon in pancreatic islet cells of both normal and diabetic patients.
168	21241371	The adipokine resistin was positively and the potentially cardio-protective adiponectin was negatively correlated with the PASI (r = 0.50, P = 0.02 and r = -0.56, P = 0.007, respectively).
169	15793240	Adipose tissue gene expression in transgenic mice is characterized by decreased expression of leptin and resistin and increased expression of adiponectin, peroxisome proliferator-activated receptor gamma, and uncoupling protein 2.
170	21733717	In vitro, leptin and resistin induced increased factor Xa activity (leptin: 4.29�0.57-fold, p<0.05; resistin 4.19�0.7-fold, p<0.05 vs. control) on HUVECs as also reflected by elevated TF mRNA and protein expression.
171	21248294	Prior studies have found that in individuals with CKD, leptin is associated with fat mass but resistin is not and the associations with adiponectin are conflicting.
172	21885493	Spearman correlations and multivariable regressions were used to examine whether resistin levels were associated with SLE, disease-specific and inflammatory markers, insulin resistance, and CAC.
173	21885493	Resistin level did not correlate with markers of insulin resistance or body adiposity, including homeostatic model assessment or BMI.
174	21885493	Among subjects with SLE, higher resistin level correlated positively with renal dysfunction, inflammatory markers, and disease damage but not with insulin resistance or BMI.
175	21995154	Resistin is a potent regulator of glucose homeostasis which is thought to oppose the action of insulin in peripheral tissues.