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Gene Information
Gene symbol: RNF123
Gene name: ring finger protein 123
HGNC ID: 21148
Synonyms: FLJ12565
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | C10orf46 | 1 hits |
| 2 | CISH | 1 hits |
| 3 | INS | 1 hits |
| 4 | IRS2 | 1 hits |
| 5 | JUNB | 1 hits |
| 6 | MAP3K2 | 1 hits |
| 7 | PRICKLE1 | 1 hits |
| 8 | RHOA | 1 hits |
| 9 | SOCS1 | 1 hits |
| 10 | TP53 | 1 hits |
| 11 | TRIM37 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12228220 | Mutations in the conserved SOCS box of SOCS1 abrogated its interaction with the elongin BC ubiquitin-ligase complex without affecting its binding to IRS1 or IRS2. |
| 2 | 12228220 | Thus, SOCS-mediated degradation of IRS proteins, presumably via the elongin BC ubiquitin-ligase, might be a general mechanism of inflammation-induced insulin resistance, providing a target for therapy. |
| 3 | 16306379 | MUL is caused by mutations in the TRIM37 gene, encoding a peroxisomal protein (TRIM37) with E3 ubiquitin-ligase activity. |
| 4 | 16871767 | Cullin family proteins organize ubiquitin ligase complexes to target numerous cellular proteins for polyubiquitinylation and subsequent proteasomal degradation. |
| 5 | 21123956 | Statins has been demonstrated to facilitate p53 degradation by activating its specific ubiquitin ligase, MDM2. |
| 6 | 21454619 | The HECT-type ubiquitin ligase (E3) Smad ubiquitination regulatory factor 1 (Smurf1) targets various substrates, including Smad1/5, RhoA, Prickle 1, MEKK2, and JunB for degradation and thereby regulates adult bone formation and embryonic development. |