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Gene Information
Gene symbol: ROCK1
Gene name: Rho-associated, coiled-coil containing protein kinase 1
HGNC ID: 10251
Synonyms: p160ROCK
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19276091 | To investigate the physiological role of ROCK1 in the regulation of whole body glucose homeostasis and insulin sensitivity in vivo, we studied mice with global disruption of ROCK1. |
| 2 | 19276091 | Thus, our results identify ROCK1 as a novel regulator of glucose homeostasis and insulin sensitivity in vivo, which could lead to new treatment approaches for obesity and type 2 diabetes. |
| 3 | 21189360 | To determine whether serine/threonine ROCK1 is activated by insulin in vivo in humans and whether impaired activation of ROCK1 could play a role in the pathogenesis of insulin resistance, we measured the activity of ROCK1 and the protein content of the Rho family in vastus lateralis muscle of lean, obese nondiabetic, and obese type 2 diabetic subjects. |
| 4 | 21189360 | Insulin increased ROCK1 activity 2.1-fold in lean and 1.7-fold in obese nondiabetic subjects in muscle. |
| 5 | 21189360 | However, ROCK1 activity did not increase in response to insulin in muscle of obese type 2 diabetic subjects without change in ROCK1 protein levels. |