Ignet

Gene Information

Gene symbol: RPS27A

Gene name: ribosomal protein S27a

HGNC ID: 10417

Synonyms: UBCEP80, Uba80, S27A

Related Genes

#	Gene Symbol	Number of hits
1	CD68	1 hits
2	CHAT	1 hits
3	CIDEC	1 hits
4	COL1A1	1 hits
5	EGF	1 hits
6	EGFR	1 hits
7	FBXO32	1 hits
8	FGF7	1 hits
9	FOXO3	1 hits
10	GCG	1 hits
11	GHR	1 hits
12	HDAC9	1 hits
13	HGS	1 hits
14	IDE	1 hits
15	IGF1R	1 hits
16	INS	1 hits
17	IRS1	1 hits
18	IRS2	1 hits
19	JUN	1 hits
20	KDR	1 hits
21	KRT8	1 hits
22	MAP3K7	1 hits
23	MAPT	1 hits
24	MDM2	1 hits
25	SOCS1	1 hits
26	SOCS3	1 hits
27	SPG20	1 hits
28	TNFAIP3	1 hits
29	TRIM37	1 hits
30	UBC	1 hits
31	UCP2	1 hits
32	USP15	1 hits

Related Sentences

#	PMID	Sentence
1	12228220	We show that SOCS1 or SOCS3 targeted IRS1 and IRS2, two critical signaling molecules for insulin action, for ubiquitin-mediated degradation.
2	15140202	Cerebral proteasome function is reduced and ubiquitin and p53 accumulate in these brain regions, with the subsequent activation of a p53-dependent transgene and the endogenous Mdm2 gene.
3	15562254	The increased expression of this deubiquitinating enzyme under conditions of increased proteolysis suggests that it may play a role in regeneration of free ubiquitin either coincident with or after proteasome-mediated degradation of substrates.
4	16505224	Plaques were analyzed for macrophages (CD68), T-cells (CD3), inflammatory cells (HLA-DR), ubiquitin, proteasome 20S activity, nuclear factor (NF)-kappaB, inhibitor of kappaB (IkappaB)-beta, tumor necrosis factor (TNF)-alpha, nitrotyrosine, matrix metalloproteinase (MMP)-9, and collagen content (immunohistochemistry and enzyme-linked immunosorbent assay).
5	17100991	This was confirmed by the identification of two novel mutations in tripartite motif protein 37 (TRIM37) encoding a RING finger ubiquitin E3 ligase.
6	17445799	The UIM (Ubiquitin Interacting Motif) domain of Hrs is required for Hrs-induced increases in VEGF-R2, but not in IR.
7	17805301	Here we show in mice that insulin inhibits gluconeogenic gene expression during re-feeding by promoting the phosphorylation and ubiquitin-dependent degradation of TORC2.
8	18586085	Here we overview downregulation of the growth hormone receptor as the most specific and potent mechanism of restricting cellular responses to growth hormone and analyze the role of several proteolytic systems and, specifically, ubiquitin-dependent pathways in this regulation.
9	19387108	In HFD fed mice, temporal lobe levels of ubiquitin (P<0.001) and 4-hydroxynonenal (P<0.05 or P<0.01) increased, and tau, beta-actin, and choline acetyltransferase levels decreased (P<0.05-P<0.001) with development of NASH.
10	19793100	The HDACs are also regulated by ubiquitin-mediated proteasomal degradation, although the exact mediators of this process have not been identified. 5.
11	21029310	Evidence for proteasomal turnover of UCP2 includes sensitivity of degradation to classic proteasome inhibitors in cells, and reconstitution of degradation in vitro in mitochondria incubated with ubiquitin and the cytosolic 26S proteasome.
12	20719964	The SPG20 protein spartin localizes to lipid droplets and endosomes, and it interacts with tail interacting protein 47 (TIP47) as well as the ubiquitin E3 ligases atrophin-1-interacting protein (AIP)4 and AIP5.
13	21031338	It could be shown that the applied anabolic combination significantly influenced the expression of the steroid receptor ER?, the keratinization factor CK8, the proinflammatory interleukins IL-1? and IL-1?, the growth factors FGF7, EGF, EGFR, IGF-1R, TGF? and LTF, the oncogen c-jun and other factors like actin? and ubiquitin 3.
14	20089860	Here, we show that Fsp27 stability is controlled by the ubiquitin-dependent proteasomal degradation pathway in adipocytes.
15	21185309	From these criteria, we predict that IDE can cleave and inactivate ubiquitin (Ub).
16	21421051	On-column cleavage of the refolded K6UbGLP-1 with ubiquitin-specific protease 1 gave an authentic form of GLP-1.
17	20371624	The PI3K/Akt pathway inhibits the FOXO-mediated transcription of the muscle-specific E3 ligase atrogin-1/MAFbx (AT-1), whereas the MEK/ERK pathway increases Sp1 activity and ubiquitin (UbC) expression.
18	20371624	We conclude that FOXO3a mediates a reciprocal communication between the IRS-1/PI3K/Akt and IRS-2/MEK/ERK pathways that coordinates AT-1 and ubiquitin expression during muscle atrophy.
19	18653708	Insulin replacement prevented the decrease in IRS-1/Akt phosphorylation, the increase in proteolysis, and attenuated the increase in ubiquitin mRNA.
20	18952128	Although A20 is mostly localized in the cytosol, our recent studies reveal that a fraction of A20 can associate with a lysosome-interacting compartment in a manner that requires its carboxy terminal zinc fingers, but independent of its ubiquitin modifying activities.
21	18952128	This process is dependent on the membrane tethering zinc finger domains of A20, but does not require A20 ubiquitin modifying activity.
22	16543409	Because ubiquitination of TRAF6 is required for activation of TAK1, we analyzed the role of SOCS-3 on TRAF6 ubiquitination and found that SOCS-3 inhibited ubiquitin modification of TRAF6.