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Gene Information
Gene symbol: RPS6KA1
Gene name: ribosomal protein S6 kinase, 90kDa, polypeptide 1
HGNC ID: 10430
Synonyms: RSK, RSK1, HU-1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | EEF2 | 1 hits |
| 3 | GCG | 1 hits |
| 4 | HMOX1 | 1 hits |
| 5 | INS | 1 hits |
| 6 | KIAA1524 | 1 hits |
| 7 | MAPK1 | 1 hits |
| 8 | MAPK10 | 1 hits |
| 9 | RPS6KB1 | 1 hits |
| 10 | UBASH3B | 1 hits |
| 11 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 1380182 | By contrast, insulin stimulation of the p85 Rsk S6 kinase and mitogen-activated protein (MAP) kinase activity were unaffected by drug. |
| 2 | 11978789 | The prosurvival effects of GLP-2 on LY294002-induced cell death were independent of Akt, p90(Rsk), or p70 S6 kinase activation; were mimicked by forskolin; and were abrogated by inhibition of protein kinase A (PKA) activity. |
| 3 | 16180585 | We have examined the basal and insulin-mediated phosphorylation of protein kinase B (PKB), protein kinase Czeta (PKCzeta), p70(S6k), mitogen-activated protein kinase (MAPK)/p90(rsk) pathway and the expression of IGFBP-3, -4, and -5 in mice selected for body weight gain (line C) and reduction (line L). |
| 4 | 16180585 | In muscle of C-line mice, insulin stimulated the p90(rsk) activity to the same extent in both experimental groups (+22% over appropriate basal value). |
| 5 | 16183639 | Elongation factor 2 (EF2) is phosphorylated and inhibited by the eEF2 kinase (CaM kinase III); the latter is inhibited by the S6K or Rsk. |
| 6 | 17508911 | These novel findings provide a link between the increase in HO-1 activity, with its concurrent enhanced production of carbon monoxide (CO) and bilirubin, a decrease in infiltrated CD11c(+) dendritic cells and an increase in anti-apoptotic proteins, including RSK and BcL-xL, in the interdiction of the diabetic state. |
| 7 | 18377870 | Expression of a constitutively active form of the mTOR target ribosomal protein S6 kinase (S6K) or of translation factor eIF4E reduced apoptosis by glucose limitation, and co-expression of S6K and eIF4E protected beta cells to the same extent as active Akt. |
| 8 | 21329734 | The visfatin-induced increase in VEGF expression was also eliminated by RNA interference-mediated knockdown of the 70-kDa ribosomal protein S6 kinase (p70S6K), a downstream target of mTOR. |