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Gene Information
Gene symbol: RUNX2
Gene name: runt-related transcription factor 2
HGNC ID: 10472
Synonyms: AML3, PEBP2A1, PEBP2aA1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ALPI | 1 hits |
| 2 | ALPL | 1 hits |
| 3 | ALPP | 1 hits |
| 4 | IDDM2 | 1 hits |
| 5 | NOX4 | 1 hits |
| 6 | NR0B2 | 1 hits |
| 7 | PRKAA2 | 1 hits |
| 8 | SP7 | 1 hits |
| 9 | TNFRSF11A | 1 hits |
| 10 | TNFRSF11B | 1 hits |
| 11 | USF1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12925529 | The osteoblast factor osterix (Osx) is up-regulated 10-fold by Msx2, but Runx2 mRNA is unchanged; the early osteoblast marker alkaline phosphatase increases 50-fold with mineralized nodule formation enhanced 30-fold. |
| 2 | 17005530 | The in vitro studies demonstrated that high glucose increased the expression of the osteoblast transcription factor core binding factor alpha subunit 1 (Cbfa1) and its downstream protein osteocalcin by 1.9-fold and 1.8-fold, respectively, and ALP activity by 1.5-fold. |
| 3 | 19196804 | These skeletal alterations were associated with decreased gene expression (by real-time PCR) of Runx2, osterix, osteocalcin, PTHrP, the PTH type 1 receptor, vascular endothelial growth factor and its receptors, and osteoprotegerin to receptor activator of nuclear factor-kappaB ligand mRNA ratio, and increased peroxisome proliferator-activated receptor-gamma2 mRNA levels. |
| 4 | 20818503 | The decreased expression of ALP, osteoclacin and collagen mRNA in diabetic rats was associated with decreases in the expression of Runx2, Dlx5 and osterix and an unaltered expression of bone morphogenic protein-2. |
| 5 | 20818503 | These suggested that short-term IDDM induced upregulation of osteoclastogenesis with an increase in RANK and downregulation of osteoblastogenesis with a decrease in Runx2 in bone. |
| 6 | 20674184 | TNF-? and IL-1? have indeed been shown to stimulate in vitro the expression by vascular smooth muscle cells (VSMCs) of tissue-non specific alkaline phosphatase (TNAP), a key enzyme in the mineralization process, and to trigger the trans-differentiation of VSMCs into osteoblast-like cells, expressing the master transcription factor RUNX2. |
| 7 | 20489161 | SM-caPTH1R downregulated aortic Col1A1, Runx2, and Nox1 expression without altering TNF, Msx2, Wnt7a/b, or Nox4. |
| 8 | 21147283 | In addition, metformin-induced AMPK activation increased the level of Runx2 mRNA and protein. |
| 9 | 21147283 | However, USF-1 and SHP were not involved in metformin-induced Runx2 expression. |
| 10 | 21147283 | Transient transfection and chromatin immunoprecipitation assays confirmed that metformin-induced SHP interacts physically and forms a complex with Runx2 on the osteocalcin gene promoter in MC3T3E1 cells. |
| 11 | 21567076 | The decreased expression of ALP, osteoclacin and collagen mRNA was associated with a decrease in the expression of runt-related transcription factor 2 (Runx2), Osterix and distal-less homeobox 5 (Dlx5) and an unaltered expression of bone morphogenic protein-2 (BMP2). |