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Gene Information

Gene symbol: SAT1

Gene name: spermidine/spermine N1-acetyltransferase 1

HGNC ID: 10540

Synonyms: SSAT

Related Genes

#	Gene Symbol	Number of hits
1	ADIPOQ	1 hits
2	CD14	1 hits
3	CFDP1	1 hits
4	FABP4	1 hits
5	FTO	1 hits
6	IL6	1 hits
7	INS	1 hits
8	LEP	1 hits
9	LPIN1	1 hits
10	LPL	1 hits
11	MCL1	1 hits
12	RBP4	1 hits

Related Sentences

#	PMID	Sentence
1	22025778	Individuals with CLS in SAT exhibited upregulation of matrix metalloproteinase-9 and monocyte antigen CD14 genes, as well as several other genes belonging to the nuclear factor-?B (NF-?B) stress pathway.
2	21645024	We analysed RBP4 mRNA expression by real-time PCR, protein expression by Western blot and immunohistochemistry, and secretion of EAT and SAT explants from CAD and non-CAD patients by Enzyme Immunoassay.
3	12660870	Thus, visceral cells transfer and release fatty acids more extensively, have increased glucocorticoid and reduced thiazolidinedione responses, produce more angiotensinogen, interleukin-6 and plasminogen activator inhibitor-1, and secrete less leptin and adiponectin than SAT.
4	19622624	A down-regulation of ZAG in SAT, VAT, and liver exists in obese patients but seems unrelated to insulin resistance.
5	19763711	SAT FTO mRNA expression was related to fasting glucose and waist circumference only.
6	19763711	SAT FTO mRNA expression was related to SAT tumor necrosis factor-alpha and nuclear factor-kappaB mRNA expression.
7	20353437	We found that PA significantly stimulated leptin mRNA expression and secretion by OAT and SAT, whereas it had no effect on adiponectin.
8	21498926	Adiponectin gene expression in EAT and PAT were significantly lower in MS group compared to the control group (p<0.0001, p=0.04, respectively) while SAT adiponectin gene expression did not differ significantly (p=0.64).
9	21498926	Our results demonstrate that TNF-? and leptin gene expressions increase prominently in the EAT, PAT and SAT while adiponectin gene expression decreases significantly in EAT and PAT in MS patients with CAD.
10	21060977	Measurements were made of VAT and SAT SCD1, SREBP-1 and ATPase p97 mRNA expression and protein levels.
11	21060977	However, SAT SCD1 protein levels were increased in morbidly obese patients with higher insulin resistance (P < 0.05).
12	21060977	Multiple linear regressions in the morbidly obese patients showed that the variable associated with the SCD1 protein levels in VAT was insulin resistance, and the variables associated with SCD1 protein levels in SAT were body mass index (BMI) and ATPase p97.
13	20530740	Our aim was to perform a cross-sectional analysis of VAT compared with subcutaneous (SAT) LPIN1 expression in a well-characterized obese cohort, its relation with the expression of genes involved in lipid metabolism, and the in vitro response to lipogenic and lipolytic stimuli.
14	21966368	VLDL receptor (VLDLR), lipoprotein lipase (LPL), acylation stimulating protein (ASP), LDL receptor-related protein 1 (LRP1) and fatty acid binding protein 4 (FABP4) gene expression was measured in VAT and SAT from 28 morbidly obese patients with Type 2 Diabetes Mellitus (T2DM) or high IR, 10 morbidly obese patients with low IR, 10 obese patients with low IR and 12 lean healthy controls.
15	21966368	BMI, plasma insulin levels and HOMA-IR correlated negatively with LPL expression in both VAT and SAT as well as with FABP4 expression in VAT.
16	21966368	FABP4 gene expression in SAT correlated inversely with BMI and HOMA-IR.
17	21966368	However, multiple regression analysis showed that BMI was the main variable contributing to LPL and FABP4 gene expression in both VAT and SAT.
18	21865369	In addition, there were significantly increased numbers of macrophages infiltrating the SAT of MetS and increased numbers of crown-like structures compared with controls. hsCRP correlated positively with homeostasis model assessment and SAT MCP-1 and negatively with adiponectin.