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Gene Information
Gene symbol: SCN5A
Gene name: sodium channel, voltage-gated, type V, alpha subunit
HGNC ID: 10593
Synonyms: Nav1.5, LQT3, HB1, HBBD, PFHB1, IVF, HB2, HH1, SSS1, CDCD2, CMPD2, ICCD
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AQP2 | 1 hits |
| 2 | AVP | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16159898 | Semiquantitative confocal immunofluorescence microscopy of AQP2 immunolabeling showed reduced AQP2 expression in the apical plasma membrane domain in connecting tubule (CNT) and initial cortical collecting ducts (iCCD) in response to aldosterone-treated rats compared with rats treated with lithium only. |
| 2 | 16159898 | Spironolactone significantly increased apical AQP2 expression in the iCCD compared with rats treated with lithium only. |
| 3 | 16159898 | This study shows that aldosterone treatment perturbs diabetes insipidus and is associated with AQP2 redistribution in CNT and iCCD likely mediated by the spironolactone-sensitive mineralocorticoid receptor. |