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Gene Information
Gene symbol: SETD2
Gene name: SET domain containing 2
HGNC ID: 18420
Synonyms: HYPB, HIF-1, KIAA1732, FLJ23184, KMT3A
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | HIF1A | 1 hits |
| 3 | INS | 1 hits |
| 4 | PCBP1 | 1 hits |
| 5 | PDGFA | 1 hits |
| 6 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19845601 | Daily treatment of prostate cancer xenograft-bearing mice with low-dose anthracycline (doxorubicin or daunorubicin) chemotherapy inhibits HIF-1 DNA-binding activity, HIF-1-dependent expression of angiogenic growth factors, mobilization of circulating angiogenic cells, and tumor vascularization, thereby arresting tumor growth. |
| 2 | 19443196 | Furthermore, the amounts of hypoxic-induced factor (HIF) 1 alpha mRNA and protein, the major regulator of VEGF and PDGF, also showed up-regulation by ferulic acid. |
| 3 | 19443196 | Moreover, inhibitors of extracellular-signal-regulated kinase 1/2 and phosphoinositide-3 kinase (PI3K) abolished the binding activity of HIF-1 alpha and the subsequent activation of VEGF and PDGF production by ferulic acid. |
| 4 | 21873554 | Mice with adipocyte-specific targeted disruption of the genes encoding the HIF1 obligatory subunits Hif1? or Arnt (Hif1?) were generated using an aP2-Cre transgene with the Cre/LoxP system. |
| 5 | 21873554 | Inhibition of HIF1 in adipose tissue ameliorates obesity and insulin resistance. |
| 6 | 22055506 | Depletion of PCBP1 or PCBP2 in cells led to loss of PHD activity, manifested by reduced prolyl hydroxylation of HIF1?, impaired degradation of HIF1? through the VHL/proteasome pathway, and accumulation of active HIF1 transcription factor. |