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Gene Information
Gene symbol: SH2B1
Gene name: SH2B adaptor protein 1
HGNC ID: 30417
Synonyms: FLJ30542, SH2B
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | JAK2 | 1 hits |
| 3 | LEP | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21907990 | Variability at the SH2B1 obesity locus is associated with MI in diabetic patients and with reduced insulin-stimulated NOS activity in human endothelial cells. |
| 2 | 15767667 | Consistent with previous reports, we further show that the SH2 domains of SH2-B and APS bind JAK2 at Tyr813. |
| 3 | 15767667 | At lower levels of SH2-B or APS expression, dimerization approximates two JAK2 molecules to induce transactivation. |
| 4 | 20417156 | Here, we identified dSH2B as the Drosophila homolog of SH2B1. dSH2B bound to Chico and directly promoted insulin-like signaling. |
| 5 | 20484460 | Single-nucleotide polymorphisms in the SH2B1 loci and chromosomal deletions of the SH2B1 loci associate with obesity and insulin resistance in humans. |
| 6 | 20484460 | In cultured cells, SH2B1 promotes leptin and insulin signaling by binding via its SH2 domain to phosphorylated tyrosines in Janus kinase 2 and the insulin receptor, respectively. |