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Gene Information
Gene symbol: SIRT3
Gene name: sirtuin 3
HGNC ID: 14931
Synonyms: SIR2L3
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FOXO3 | 1 hits |
| 2 | MAPK8 | 1 hits |
| 3 | NOS2A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18781224 | Overexpression of a wild-type SIRT3 gene increase FOXO3a DNA-binding activity as well as FOXO3a dependent gene expression. |
| 2 | 21539480 | Because physical inactivity may share elevated pro-inflammatory (tumor necrosis factor-alpha and inducible nitric oxide synthase) and insufficient stress response (insulin-like growth factor-1 [IGF-1], heat-shock protein 25 [HSP25], NAD-dependent deacetylase sirtuin-3 [SIRT-3], and peroxisome proliferator-activated receptor-gamma coactivator 1[PGC-1?]) signaling with aging and chronic disease, it is critical to distinguish true aging from chronic inactivity or underlying disease. |
| 3 | 21873205 | Sirt3 knockout mice exhibit decreased oxygen consumption and develop oxidative stress in skeletal muscle, leading to JNK activation and impaired insulin signaling. |