Ignet

Gene Information

Gene symbol: SLC30A8

Gene name: solute carrier family 30 (zinc transporter), member 8

HGNC ID: 20303

Related Genes

#	Gene Symbol	Number of hits
1	CDKN2B	1 hits
2	IGFBP2	1 hits
3	INS	1 hits
4	SLC30A10	1 hits
5	SLC30A3	1 hits
6	SLC39A3	1 hits

Related Sentences

#	PMID	Sentence
1	17786204	By genotyping of 921 metabolically characterized German subjects for the reported candidate single nucleotide polymorphisms (SNPs), we show that the major alleles of the SLC30A8 SNP rs13266634 and the HHEX SNP rs7923837 associate with reduced insulin secretion stimulated by orally or intravenously administered glucose, but not with insulin resistance.
2	18461161	In the overall group of French subjects (4,232 T2D and 4,595 NGT), IGFBP2 and CXCR4 synergistically interacted with (LOC38776, SLC30A8, HHEX) and (NGN3, CDKN2A/2B), respectively, encoding for proteins presumably regulating pancreatic endocrine cell development and function.
3	19655390	In pancreatic islets, insulin production is linked with zinc transport mediated by zinc transporter ZnT-8, a product of the SLC30A8 gene.
4	19655390	Therefore, altered activity of ZnT-8 is expected to be associated with impaired glucose-induced insulin response and promote progression from glucose intolerance to diabetes.
5	20490449	In this issue of Diabetologia, Wijesekara and colleagues, using a cell-specific Znt8 (also known as Slc30a8) knockout model, demonstrate that beta cell insulin processing and glucose tolerance is negatively affected after beta cell knock out of Znt8, whereas Znt8 knockout in alpha cells seems to have little effect on glucagon secretion or glucose tolerance.
6	21208276	Insulin secretion was significantly reduced by ZnT3 knock-down, whereas knock-down of ZnT8 resulted in increased intracellular content of insulin accompanied by a relatively lowered secretion.
7	17463246	With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D-in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1-and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study.
8	21067978	ZnT8 autoantibodies (ZnT8A) were determined by radioimmunoassay using carboxy-terminal ZnT8 constructs in 57 childhood-onset, 97 adult-onset, and 85 fulminant T1D.
9	21099260	As a first step towards understanding the pathogenic role of ZnT8 in diabetes, we evaluated the expression of ZnT8 in mouse pancreas.
10	21099294	The author's laboratory and others have now developed knockout mouse models for the ZnT8 gene, and have studied the impact of the at-risk R325W polymorphism on the activity of this crucial islet zinc transporter.
11	21461562	ZnT-8 has been suggested as a potential candidate in the regulation of insulin secretion in pancreatic ?-cells.
12	20351753	We tested the hypothesis that the polymorphic residue at position 325 of ZnT-8 determines the susceptibility to cyclosporin A (CsA) suppression of insulin secretion.
13	20351753	A reduced number of insulin granule fusion events accompanied the decrease in insulin secretion in CsA-treated cells expressing ZnT-8 R325; however, ZnT-8 W325-expressing cells exhibited resistance to the dampening of insulin granule fusion by CsA, and transported zinc ions into secretory vesicles more efficiently.
14	20351753	These data suggest that the ZnT-8 W325 variant is protective against CsA-induced suppression of insulin secretion.
15	21779873	We found that increasing dosage of the C risk allele at SLC30A8 rs13266634 was significantly associated with higher proinsulin levels at baseline (p?=?0.002) after adjustment for baseline insulin.
16	21779873	At the 1 year analysis, proinsulin levels decreased significantly in all groups receiving active intervention and were no longer associated with SLC30A8 genotype (p?=?0.86) after adjustment for insulin at baseline and 1 year.
17	21437630	TCF7L2 and SLC30A8 have been found to be associated with type 2 diabetes mellitus (T2DM) as well as with impaired proinsulin processing recently, enzymes encoded by PCSK1 and PCSK2 are reported to play an important role in the process of proinsulin conversion.
18	21437630	To investigate whether the single nucleotide polymorphisms (SNPs) of TCF7L2, SLC30A8, PCSK1 and PCSK2 were associated with T2DM as well as with proinsulin conversion in a Han Chinese population from Chongqing.
19	21437630	Rs13266634 at SLC30A8 had a tendency to be associated with fasting plasma levels of proinsulin (P�=�0.0639 in additive model).