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Gene Information
Gene symbol: SLC5A1
Gene name: solute carrier family 5 (sodium/glucose cotransporter), member 1
HGNC ID: 11036
Synonyms: D22S675, NAGT
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FARP2 | 1 hits |
| 2 | INS | 1 hits |
| 3 | RSC1A1 | 1 hits |
| 4 | SGK1 | 1 hits |
| 5 | SLC2A1 | 1 hits |
| 6 | SLC2A2 | 1 hits |
| 7 | SLC5A2 | 1 hits |
| 8 | TAS1R3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16186415 | In the apical GLUT2 model, the glucose transported by the Na(+)/glucose cotransporter SGLT1 promotes insertion of GLUT2 into the apical membrane within minutes, so that the mechanism operates during assimilation of a meal containing high-glycemic index carbohydrate to provide a facilitated component of absorption up to three times greater than by SGLT1. |
| 2 | 17050778 | By examining a Chinese hamster ovary-K1 cell line stably expressing either human SGLT2 or human high-affinity sodium glucose cotransporter (SGLT1), we found sergliflozin-A (active form) to be a highly selective and potent inhibitor of human SGLT2. |
| 3 | 17686765 | The human gene RSC1A1 codes for a 67-kDa protein named RS1 that mediates transcriptional and post-transcriptional regulation of Na(+)-D-glucose cotransporter SGLT1. |
| 4 | 17686765 | We identified two tripeptides in human RS1 (Gln-Cys-Pro (QCP) and Gln-Ser-Pro (QSP)) that induce posttranscriptional down-regulation of SGLT1 at the TGN leading to 40-50% reduction of SGLT1 in plasma membrane. |
| 5 | 17724332 | Dietary sugar and artificial sweeteners increased SGLT1 mRNA and protein expression, and glucose absorptive capacity in wild-type mice, but not in knockout mice lacking T1R3 or alpha-gustducin. |
| 6 | 18178160 | Insulin treatment also led to the up-regulation of human sodium/glucose transporter 1 (hSGLT1), which further increases intracellular glucose levels. |
| 7 | 19764891 | SGK1 activates ion channels (including ENaC, TRPV5, ROMK, KCNE1/KCNQ1 and CLCKa/Barttin), carriers (including NCC, NKCC, NHE3, SGLT1 and EAAT3), and the Na(+)/K(+)-ATPase. |
| 8 | 19965550 | Mutations in SGLT1 are associated with glucose-galactose malabsorption, SGLT2 with familial renal glucosuria (FRG), and GLUT2 with Fanconi-Bickel syndrome. |
| 9 | 20980548 | Phlorizin exhibited higher affinity with hSGLT2 (K(i) 11 vs. 140 nM) and a lower Off-rate (0.03 vs. 0.2 s?¹) compared with hSGLT1. |
| 10 | 21358696 | GLUT1 and GLUT2 are associated with SGLT1 and SGLT2, respectively. |