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Gene Information
Gene symbol: SLC5A5
Gene name: solute carrier family 5 (sodium iodide symporter), member 5
HGNC ID: 11040
Synonyms: NIS
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | SLC26A4 | 1 hits |
| 2 | SLC2A2 | 1 hits |
| 3 | TG | 1 hits |
| 4 | TSHR | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11134119 | Autoradiography revealed that full-length hNIS was expressed, recognized by a NIS monoclonal antibody, and strongly bound by some sera from patients with autoimmune thyroid disease, which did not react with the GLUT-2 control protein. |
| 2 | 11137035 | For example, whereas follicular thyroglobulin suppresses the gene expression and activity of the sodium iodide symporter (NIS), it increases pendrin gene expression. |
| 3 | 20427476 | We describe the first small-molecule ligand [1;2-(3-((2,6-dimethylphenoxy)methyl)-4-methoxyphenyl)-3-(furan-2-ylmethyl)-2,3-dihydroquinazolin-4(1H)-one] that exhibits inverse agonist properties at TSHR. 1 inhibits basal and TSH-stimulated signaling, measured as cAMP production, by TSHRs in HEK-EM 293 cells stably expressing wild-type TSHRs; the antagonism of TSH-mediated signaling is competitive. 1 also inhibits basal signaling by wild-type TSHRs, and four constitutively active mutants of TSHR expressed transiently in HEK-EM 293 cells. 1 was active under more physiologically relevant conditions in primary cultures of human thyrocytes expressing endogenous TSHRs where it inhibited basal levels of mRNA transcripts for thyroglobulin, thyroperoxidase, sodium iodide symporter, and TSHR. |