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Gene Information
Gene symbol: SMAD1
Gene name: SMAD family member 1
HGNC ID: 6767
Synonyms: MADR1, JV4-1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACTC1 | 1 hits |
| 2 | ACVRL1 | 1 hits |
| 3 | AGT | 1 hits |
| 4 | BMP4 | 1 hits |
| 5 | BMP7 | 1 hits |
| 6 | BMPR1A | 1 hits |
| 7 | INHBE | 1 hits |
| 8 | NOS2A | 1 hits |
| 9 | SOSTDC1 | 1 hits |
| 10 | SPP1 | 1 hits |
| 11 | TCF7L2 | 1 hits |
| 12 | TGFB1 | 1 hits |
| 13 | TMEM119 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16767106 | Here we examined the effect of Ang II on the expression of Smad1 and mesangial matrix expansion in streptozotocin (STZ)-induced diabetic rats in vivo, using Ang II type 1 receptor blocker, olmesartan. |
| 2 | 16767106 | Taken together, these results indicate that Ang II can regulate the development of mesangial matrix expansion in the early phase of diabetic nephropathy through Src and Smad1. |
| 3 | 17804487 | In these cells, BMP7 effectively activates smad5 (but not smad1) and raises p38 phosphorylation [which is also increased by transforming growth factor-beta (TGF-beta)]. |
| 4 | 19255250 | BMP signaling activity was visualized by phosphorylated Smad1, -5, and -8 (pSmad1/5/8) immunostaining, and related to expression of CTGF, SOSTDC1, and the podocyte differentiation markers WT1, synaptopodin, and nephrin. |
| 5 | 20803090 | The expressions of TCF7L2 and ALK1 were induced by advanced glycation end products (AGEs) in parallel with Smad1, phosphorylated Smad1 (pSmad1), and alpha-smooth muscle actin (?-SMA) through TGF-?1 in cultured mesangial cells. |
| 6 | 20803090 | Overexpression of TCF7L2 increased the expressions of ALK1 and Smad1. |
| 7 | 20803090 | Inversely, TCF7L2 knockdown by siRNA suppressed ?-SMA expression as well as ALK1 and Smad1. |
| 8 | 20803090 | The iNOS transgenic mice (iNOS-Tgm), which developed diabetic glomerulosclerosis resembling human diabetic nephropathy, exhibited markedly increased expressions of ALK1, TCF7L2, Smad1, pSmad1, and ?-SMA in glomeruli in association with mesangial matrix expansion. |
| 9 | 21476304 | Smad1 also regulated other ECM proteins, such as type I collagen and osteopontin, as well as alpha smooth muscle actin. |
| 10 | 21239498 | Tmem119 interacted with Runx2, Smad1, and Smad5 in C2C12 cells. |
| 11 | 21471216 | Moreover, Bmp4 utilized Alk3 and affected the activation of Smad1 and Col4 expressions in mesangial cells. |
| 12 | 9436357 | Smad family members (Smad 1, Smad 2, Smad 3 and Smad 4) are expressed in the cultured retinal pigmant epithelial cell line (D407), in which TGF-beta and activin A stimulate the translocation of Smad 2, but not Smad 1 into nuclei, whereas bone morphogenetic protein (BMP) stimulates that of Smad 1, but not Smad 2. |