- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: SMAD2
Gene name: SMAD family member 2
HGNC ID: 6768
Synonyms: MADR2, JV18-1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AGT | 1 hits |
| 2 | BMP3 | 1 hits |
| 3 | COL1A1 | 1 hits |
| 4 | FOXM1 | 1 hits |
| 5 | INHBE | 1 hits |
| 6 | INS | 1 hits |
| 7 | MCL1 | 1 hits |
| 8 | TGFB1 | 1 hits |
| 9 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21143387 | In cardiomyocytes, CM from EAT of HFD-fed animals increased SMAD2-phosphorylation, a marker for activin A-signalling, decreased sarcoplasmic-endoplasmic reticulum calcium ATPase 2a expression, and reduced insulin-mediated phosphorylation of Akt-Ser473 versus CM from SAT and standard diet-fed animals. |
| 2 | 15840669 | The expression of alpha3(IV) collagen was influenced by the TGF-beta system, but AngII did not increase the podocyte's production of TGF-beta1 ligand; rather, it increased the expression of the TGF-beta type II receptor and activated the TGF-beta signalling system through Smad2. |
| 3 | 16556868 | Finally, activation of Smad3 but not Smad2 was a key and necessary mechanism of Ang II-induced vascular fibrosis because Ang II induced Smad3/4 promoter activities and collagen matrix expression was abolished in VSMCs null for Smad3 but not Smad2. |
| 4 | 16556868 | Activation of Smad3 but not Smad2 is a key mechanism by which Ang II mediates arteriosclerosis. |
| 5 | 17427197 | TGF-beta1, via TGF-beta receptors I (TbetaRI) and TbetaRII, activates Smad2 and mitogen-activated protein kinases p44 and p42 (p42/44(mapk)). |
| 6 | 18951876 | In this study, human insulin promoter was activated by Smad2, Smad3 and the pancreatic and duodenal homeobox factor-1 (PDX-1) in the ALK7 pathway. |
| 7 | 19188426 | Furthermore, we investigated other possible mechanisms involved in this pathogenesis: alterations in the levels of vascular endothelial growth factor (VEGF) or phosphorylated Smad2 (the latter can be induced by both glycation products and VEGF). |
| 8 | 20530742 | Sustained activation or inhibition of the activin A pathway impairs or promotes, respectively, adipocyte differentiation via the C/EBP?-LAP and Smad2 pathway in an autocrine/paracrine manner. |
| 9 | 17267584 | Pioglitazone rapidly increased the extracellular TGF-beta1 levels and concomitantly induced phosphorylation of Smad2 in VSMC from DP and NDP. |
| 10 | 9436357 | Smad family members (Smad 1, Smad 2, Smad 3 and Smad 4) are expressed in the cultured retinal pigmant epithelial cell line (D407), in which TGF-beta and activin A stimulate the translocation of Smad 2, but not Smad 1 into nuclei, whereas bone morphogenetic protein (BMP) stimulates that of Smad 1, but not Smad 2. |
| 11 | 21628466 | Interestingly, treatment of naïve INS-1 cells or murine organotypic islet cultures with recombinant human BMP-3 potently increased their insulin levels and restored the decrease in SMAD2 phosphorylation and insulin gene expression induced by the HNF1A frameshift mutation. |