Ignet

Gene Information

Gene symbol: SMAD3

Gene name: SMAD family member 3

HGNC ID: 6769

Synonyms: JV15-2, HsT17436

Related Genes

#	Gene Symbol	Number of hits
1	AGT	1 hits
2	ALPP	1 hits
3	COL1A1	1 hits
4	EPHB2	1 hits
5	FOXM1	1 hits
6	HDAC4	1 hits
7	IHG1	1 hits
8	INS	1 hits
9	INSR	1 hits
10	MIRN206	1 hits
11	PIK3CA	1 hits
12	PITRM1	1 hits
13	PTH	1 hits
14	S100A8	1 hits
15	SERPINE1	1 hits
16	SMAD7	1 hits
17	TGFB1	1 hits
18	TGFB3	1 hits
19	TMEM119	1 hits
20	TSPYL2	1 hits

Related Sentences

#	PMID	Sentence
1	15154911	The use of mice with a targeted deletion of Smad3, one of the two homologous proteins which signals from TGF-beta/activin, shows that most of the pro-fibrotic activities of TGF-beta are mediated by Smad3.
2	15154911	The loss of Smad3 also interferes with TGF-beta-mediated induction of EMT and genes for collagens, plasminogen activator inhibitor-1 and the tissue inhibitor of metalloprotease-1.
3	16556868	Finally, activation of Smad3 but not Smad2 was a key and necessary mechanism of Ang II-induced vascular fibrosis because Ang II induced Smad3/4 promoter activities and collagen matrix expression was abolished in VSMCs null for Smad3 but not Smad2.
4	16556868	Activation of Smad3 but not Smad2 is a key mechanism by which Ang II mediates arteriosclerosis.
5	18508967	IHG-1 was found to amplify TGF-beta1-mediated transcriptional activity by increasing and prolonging phosphorylation of Smad3.
6	18951876	In this study, human insulin promoter was activated by Smad2, Smad3 and the pancreatic and duodenal homeobox factor-1 (PDX-1) in the ALK7 pathway.
7	19231643	Although Smad-3 and Smad-7 immunoreactivity did not significantly differ in lesional and perilesional skin, there was a significant correlation between the protein expression of TGF-beta3 and Smad-3 (r = 0.56; P = .02), Smad-7 (r = 0.64; P = .006), and TIMP-1 (r = 0.56; P = .018) expression.
8	19265200	Transduction of adenoviral Smad3 into primary human and non-human primate islets suppresses insulin content, whereas, dominant-negative Smad3 enhances insulin levels.
9	19265200	Interestingly, Smad3-deficient islets harbor an activated insulin-receptor signaling pathway and TGF-beta signaling regulates expression of genes involved in beta-cell function.
10	19582775	We showed previously that PTH interacts with the canonical Wnt-beta-catenin signaling pathway via the transforming growth factor (TGF)-beta signaling molecule, Smad3, to modulate osteoblast differentiation and apoptosis.
11	19582775	Here, we examined which actions of Smad3 are TGF-beta-independent in stimulating the osteoblast phenotype and PTH-induced Wnt-beta-catenin signaling.
12	19582775	In contrast, MC3T3-E1 cell clones in which wild-type Smad3 was stably expressed exhibited increased ALP activity and mineralization that were decreased by the ALK5 inhibitor, SB431542, although the beta-catenin levels induced in these cells were not modulated.
13	19582775	In conclusion, the present study indicates that PTH induces osteoblast beta-catenin levels via Smad3 independently of, and dependently on, TGF-beta in the early and later induction phases, respectively.
14	19586629	Cilostazol also inhibited transactivating activity at the PAI-1 promoter by Smad3, leading to a suppression of PAI-1 gene transcription.
15	19847393	Knockdown of CDA1-encoding gene Tspyl2 to reduce cellular CDA1 level markedly attenuated TGF-beta-stimulated MAD homologue 3 (drosophila; SMAD3) phosphorylation and transcriptional activities.
16	20833210	Increased Jagged1 expression upon TGF?1 exposure required Smad3 signalling, and was also regulated by PI3K and ERK.
17	21270259	Transforming growth factor-?/Smad3 signaling has been implicated in various metabolic processes, including adipogenesis, insulin expression, and pancreatic ?-cell function.
18	21270259	Smad3-knockout mice exhibited diminished adiposity with improved glucose tolerance and insulin sensitivity.
19	15198928	These results indicate that Gly-BSA increases DNA binding activity of Smad3 and that it stimulates PAI-1 transcription through Smad-binding CAGA sequences in the PAI-1 promoter in HMC.
20	17494090	We found that, in mesangial cells and renal fibroblasts grown in eight-well chamber slides, transforming growth factor-beta1 (TGF-beta1) disrupted the cell monolayer and induced cell migration into nodules in a dose-, time- and Smad3-dependent manner.
21	18495798	TGF-beta1 also stimulated increased Smad3 phosphorylation in these cells, a response that was insensitive to inhibition of PI3K or PKB/Akt.
22	21324893	Furthermore, we present evidence that the mechanism by which miR-206 and miR-29 can inhibit the TGF-?-mediated up-regulation of HDAC4 is via the inhibition of Smad3 expression, a transducer of TGF-? signaling.
23	21239498	In conclusion, we identified a Smad3-related factor, Tmem119, that is induced by PTH and promotes differentiation in mouse osteoblastic cells.
24	21239498	Tmem119 is an important molecule in the pathway downstream of PTH and Smad3 signaling in osteoblasts.
25	21659760	It is well known that TGF-? exerts its biological effects by activating downstream mediators, called Smad2and Smad3, which is negatively regulated by an inhibitory Smad7.
26	9436357	Smad family members (Smad 1, Smad 2, Smad 3 and Smad 4) are expressed in the cultured retinal pigmant epithelial cell line (D407), in which TGF-beta and activin A stimulate the translocation of Smad 2, but not Smad 1 into nuclei, whereas bone morphogenetic protein (BMP) stimulates that of Smad 1, but not Smad 2.
27	21753123	Finally, T0901317 up-regulated the palmitic acid-induced expression of p27(KIP1), transforming growth factor beta 1, and SMAD3 proteins in INS-1 cells.