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Gene Information
Gene symbol: SMAD7
Gene name: SMAD family member 7
HGNC ID: 6773
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | COL1A1 | 1 hits |
| 2 | COL1AR | 1 hits |
| 3 | ICAM1 | 1 hits |
| 4 | SMAD3 | 1 hits |
| 5 | TGFB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19214781 | It can promote TGF-beta signalling by binding directly to the growth factor, promoting its interaction with the TGF-beta receptor; by triggering intracellular signalling on binding the TrkA receptor, which leads to the transcriptional repression of Smad7, an inhibitor of the TGF-beta signalling pathway; and by binding to BMP-7 whose own signalling pathway opposing TGF-beta is inhibited, leading to enhanced TGF-beta signalling. |
| 2 | 20980457 | Although overexpression of renal Smad7 had no effect on levels of blood glucose, it significantly attenuated the development of microalbuminuria, TGF-?/Smad3-mediated renal fibrosis such as collagen I and IV and fibronectin accumulation and NF-?B/p65-driven renal inflammation including IL-1?, TNF-?, MCP-1, and ICAM-1 expression and macrophage infiltration in diabetic rats. |
| 3 | 21659760 | It is well known that TGF-? exerts its biological effects by activating downstream mediators, called Smad2and Smad3, which is negatively regulated by an inhibitory Smad7. |