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PMID |
Sentence |
1 |
17922004
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We also show that oleic acid treatment decreases the insulin sensitivity of heart muscle cells, and this sensitivity is completely restored by transfection with SNAP23.
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2 |
17922004
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Thus, SNAP23 might be a link between insulin sensitivity and the inflow of fatty acids to the cell.
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3 |
20006577
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Our results indicate that the t-SNAREs syntaxin4 and SNAP23 are indispensable for the tethering of GLUT4 vesicles to the plasma membrane, whereas the v-SNARE VAMP2 is not required for this step but is essential for the subsequent fusion event.
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4 |
20460426
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Our previous studies suggest that the SNARE protein synaptosomal-associated protein of 23 kDa (SNAP23) is involved in the link between increased lipid levels and insulin resistance in cardiomyocytes.
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5 |
20460426
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The objective was to determine whether SNAP23 may also be involved in the known association between lipid accumulation in skeletal muscle and insulin resistance/type 2 diabetes in humans, as well as to identify a potential regulator of SNAP23.
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6 |
20460426
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Studies in L6 cells showed that Munc18c promoted the expression of SNAP23.
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7 |
20460426
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We also showed that Munc18c is a potential regulator of SNAP23.
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8 |
21596547
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SNAP23 is involved in the insulin dependent translocation of GLUT4 to the plasma membrane, and has an important role in the development of insulin resistance.
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9 |
21596547
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Thus fatty acids relocalize SNAP23 from the plasma membrane (and the translocation of GLUT 4) to the interior of the cell giving rise to insulin resistance.
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