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Gene Information
Gene symbol: SNF1LK2
Gene name: SNF1-like kinase 2
HGNC ID: 21680
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACACB | 1 hits |
| 2 | ATIC | 1 hits |
| 3 | BCL2A1 | 1 hits |
| 4 | CRTC2 | 1 hits |
| 5 | EP300 | 1 hits |
| 6 | FASN | 1 hits |
| 7 | INS | 1 hits |
| 8 | MLXIPL | 1 hits |
| 9 | PRKAA2 | 1 hits |
| 10 | SCD | 1 hits |
| 11 | SREBF1 | 1 hits |
| 12 | TMPRSS11D | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15068958 | Contraction, phenformin, or AICAR did not significantly increase activities or expression of the AMPK-related kinases QSK, QIK, MARK2/3, and MARK4 in skeletal muscle. |
| 2 | 17805301 | Insulin disrupts TORC2 activity by induction of the Ser/Thr kinase SIK2, which we show here undergoes AKT2-mediated phosphorylation at Ser 358. |
| 3 | 17805301 | Activated SIK2 in turn stimulated the Ser 171 phosphorylation and cytoplasmic translocation of TORC2. |
| 4 | 18239551 | Electroporation was used to transiently transfect 3T3-L1 adipocytes with fatty acid synthase (FAS) promoter-driven luciferase construct to evaluate the effect of SIK2 on FAS transcription. |
| 5 | 18239551 | Overexpression of SIK2 repressed the expression of lipogenic genes, including FAS, acetyl CoA carboxylase 2 (ACC2), and stearoyl CoA desaturase 1 (SCD1), and reduced triglyceride content. |
| 6 | 18239551 | Reduction of endogenous SIK2 expression through RNA interference increased the expression of FAS, ACC2, and SCD1. |
| 7 | 18239551 | This effect is independent of adenosine monophosphate-activated protein kinase (AMPK) since neither phosphorylation state nor protein level of AMPKalpha1 and AMPKalpha2 was affected by SIK2 overexpression. |
| 8 | 18239551 | SIK2 inhibits the expression of FAS-promoter driven luciferase reporter gene, and this effect can be reversed by overexpression of constitutively active sterol regulatory element binding protein-1 (SREBP-1). |
| 9 | 18239551 | Furthermore, SIK2 also reduces the nuclear translocation of endogenous SREBP-1. |
| 10 | 21084751 | In this study, we have identified the histone acetyltransferase (HAT) coactivator p300 and serine/threonine kinase salt-inducible kinase 2 (SIK2) as key upstream regulators of ChREBP activity. |
| 11 | 21084751 | SIK2 inhibited p300 HAT activity by direct phosphorylation on Ser89, which in turn decreased ChREBP-mediated lipogenesis in hepatocytes and mice overexpressing SIK2. |
| 12 | 21084751 | Finally, in mouse models of type 2 diabetes and obesity, low SIK2 activity was associated with increased p300 HAT activity, ChREBP hyperacetylation, and hepatic steatosis. |