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Gene Information
Gene symbol: SOAT1
Gene name: sterol O-acyltransferase 1
HGNC ID: 11177
Synonyms: ACAT
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD36 | 1 hits |
| 2 | CYP7A1 | 1 hits |
| 3 | GCG | 1 hits |
| 4 | GIP | 1 hits |
| 5 | LEP | 1 hits |
| 6 | LIPE | 1 hits |
| 7 | NRG1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 1598076 | Hypercholesterolemia was associated with a defect of lipoprotein receptor activity and with elevated HMG-CoA reductase and cholesterol 7 alpha - hydroxylase; conversely ACAT activity was lower in Yoshida as compared to Brown Norway rats. |
| 2 | 12200416 | However, in the presence of high glucose both insulin and leptin caused a significant increase in the activity of acyl-CoA: cholesterol O-acyltransferase (ACAT) combined with a significant reduction in the level of hormone-sensitive lipase (HSL). |
| 3 | 12200416 | Because ACAT is the main enzyme responsible for cholesterol ester synthesis and HSL contributes significantly to neutral cholesterol ester hydrolase activity, this suggests that glucose primes the J774.2 cells so that in the presence of high insulin or leptin they will store cholesterol esters. |
| 4 | 19644050 | Heregulin-beta(1), but not heregulin-alpha, significantly reduced acetylated low-density lipoprotein-induced cholesterol ester accumulation in primary cultured human monocyte-derived macrophages by reducing SR-A and ACAT1 expression and by increasing ABCA1 expression at both mRNA and protein levels. |
| 5 | 21786155 | The anti-atherosclerotic effects of GLP-1(7-36)amide and GIP(1-42) were associated with significant decreases in foam cell formation and downregulation of CD36 and acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) in macrophages. |