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Gene Information
Gene symbol: SOD3
Gene name: superoxide dismutase 3, extracellular
HGNC ID: 11181
Synonyms: EC-SOD
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ALDH9A1 | 1 hits |
| 2 | ATF3 | 1 hits |
| 3 | CLDN5 | 1 hits |
| 4 | IFNG | 1 hits |
| 5 | INS | 1 hits |
| 6 | NNAT | 1 hits |
| 7 | SOD1 | 1 hits |
| 8 | TGFB1 | 1 hits |
| 9 | TNF | 1 hits |
| 10 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15171689 | Administration of pioglitazone to 19 diabetic patients significantly increased the plasma levels of EC-SOD (69.9+/-19.3 ng/ml to 97.4+/-25.9 ng/ml; P < 0.0001) and adiponectin, while it decreased tumor necrosis factor-alpha (TNF-alpha). |
| 2 | 15131119 | These alterations exhibited 10 defined patterns and occurred in response to two distinct regulatory effects. 63 genes were identified as changed in expression depending primarily upon adipocyte size, including C/EBP-alpha, C/EBP-delta, superoxide dismutase 3, and the platelet-derived growth factor receptor. 48 genes were regulated primarily by impairment of insulin signaling, including transforming growth factor beta, interferon gamma, insulin-like growth factor I receptor, activating transcription factor 3, aldehyde dehydrogenase 2, and protein kinase Cdelta. |
| 3 | 15847948 | Total EC SOD activity, the activity of its fractions (A, B, and C) and its glycated form were determined in basal state and 30 min after intravenous (i.v.) administration of 50 mg of heparin. |
| 4 | 15847948 | Decline of EC SOD activity was observed after administration of repeated doses of heparin both in the examined and in the control groups. |
| 5 | 15847948 | Therefore, appropriate glycemic control can lead to normalization of EC SOD activity. |
| 6 | 15990193 | These results suggest that the genetic variant of EC-SOD gene is associated with insulin resistance and the susceptibility to type 2 diabetes. |
| 7 | 16857181 | Serum EC-SOD concentrations may be a sensitive biochemical marker of insulin resistance in patients with type 2 diabetes and hypertension and that losartan improves insulin sensitivity by increasing EC-SOD and adiponectin production and decreasing TNF-alpha production. |
| 8 | 20011081 | In HUVECs, EC-SOD at 100 ng/ml significantly suppressed VEGF-induced proliferation and tube formation, but not VEGF-induced migration. |
| 9 | 20594416 | From these results, it is possible that TNF-alpha is a key regulator of the reduction of EC-SOD and adiponectin in CoCl(2)-treated 3T3-L1 adipocytes, and we speculated that the reduction of EC-SOD and adiponectin would lead to and/or promote metabolic disorders. |
| 10 | 21187013 | We identified KEGG pathways significantly associated with Nnat expression, including positive correlations with inflammation and negative correlations with metabolic pathways (most prominently oxidative phosphorylation, glycolysis and gluconeogenesis, pyruvate metabolism) and protein turnover. 27 genes, including; Gstt1 and Sod3, concerned with oxidative stress; Sncg and Cxcl9 concerned with inflammation; Ebf1, Lgals12 and Fzd4 involved in adipogenesis; whose expression co-varies with Nnat were identified, and conserved transcription factor binding sites identified on their promoters. |
| 11 | 21804221 | Treatment with cobalt chloride (CoCl(2)) decreased the expression of EC-SOD but not other SOD isozymes in pericytes accompanied with an increase of intracellular ROS production. |
| 12 | 21736484 | Our observations suggest that ER stress leads to the down-regulation of claudin-5 among tight junction proteins and may induce the elevation of endothelial permeability and leakage of EC-SOD into the vitreous body. |