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Gene Information
Gene symbol: SORD
Gene name: sorbitol dehydrogenase
HGNC ID: 11184
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKR1B1 | 1 hits |
| 2 | CD59 | 1 hits |
| 3 | GLO1 | 1 hits |
| 4 | HMHB1 | 1 hits |
| 5 | INS | 1 hits |
| 6 | SDHB | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 6425821 | An increase of aldose reductase and a decrease in the sorbitol-dehydrogenase activity occur within the first two weeks after diabetes induction, which correlates with the maximal rate of sorbitol and fructose accumulation. |
| 2 | 3836706 | Erythrocyte sorbitol dehydrogenase activity was significantly lower for 34 diabetic patients (mean +/- SD: 0.219 +/- 0.085 U min-1 g Hb-1) than for 27 normal blood donors (0.34 +/- 0.094 U min-1 g Hb-1). |
| 3 | 3100473 | In the lens, the activity of aldose reductase has been observed to increase with the onset of diabetes, while the activity of sorbitol dehydrogenase decreases. |
| 4 | 2689074 | Sorbitol dehydrogenase activity in blood was increased similarly in normal, diabetic and insulin-treated diabetic mice after CCl4 administration. 7. |
| 5 | 1830528 | A spectrophotometric assay has been developed for the measurement of aldose reductase and sorbitol dehydrogenase activity in the neutrophil. |
| 6 | 8317350 | In the former group, aldose reductase activity was not decreased, but sorbitol dehydrogenase (SDH) activity was significantly increased, compared with the latter group. |
| 7 | 8344129 | Little is known about the sorbitol-dehydrogenase (SDH) activity in diabetic patients, although cataract is described in diabetes as well as in SDH deficiency. |
| 8 | 11287819 | Diabetes-induced changes in retinal metabolism and function have been linked to increased aldose reductase activity, hypoxia or 'pseudohypoxia' (increase in NADH/NAD+ attributed to increased sorbitol dehydrogenase activity). |
| 9 | 21456600 | PCA treatments at 2 and 4% significantly lowered renal activity and mRNA expression of aldose reductase and sorbitol dehydrogenase (p < 0.05), and PCA treatments only at 4% significantly enhanced renal glyoxalase I mRNA expression (p < 0.05). |