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Gene Information
Gene symbol: SPHK1
Gene name: sphingosine kinase 1
HGNC ID: 11240
Synonyms: SPHK
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | BAX | 1 hits |
| 3 | BCL2 | 1 hits |
| 4 | BCL2L11 | 1 hits |
| 5 | FOXO3 | 1 hits |
| 6 | ITGAX | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20185806 | MGL1(med)/CD11c(+) eATMPhis upregulated additional M2 genes (IL-13, SPHK1, CD163, LYVE-1, and PPAR-alpha). |
| 2 | 21625639 | Further mechanistic study examined the expression of Bcl-2 family members, including Bcl-2, Mcl-1, Bax and Bim, in SPHK1-overexpressing glioma cells and revealed that only pro-apoptotic Bim was downregulated by SPHK1. |
| 3 | 21625639 | Moreover, the transcriptional level of Bim was also altered by SPHK1 in glioma cells. |
| 4 | 21625639 | Importantly, increasing SPHK1 expression in glioma cells markedly elevated Akt activity and phosphorylated inactivation of FOXO3a, which led to downregulation of Bim. |