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Gene Information
Gene symbol: SRA1
Gene name: steroid receptor RNA activator 1
HGNC ID: 11281
Synonyms: SRA, STRAA1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | AR | 1 hits |
| 3 | CDKN1B | 1 hits |
| 4 | CTCF | 1 hits |
| 5 | FOXO1 | 1 hits |
| 6 | HNF1B | 1 hits |
| 7 | IGF2 | 1 hits |
| 8 | JUN | 1 hits |
| 9 | OLR1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 9369450 | Thus, the synergistic effects of HNF-1beta and the GR on dexamethasone-stimulated promoter activity require that they are bound to the HNF-1 site and the GRE, respectively, and may involve protein-protein interactions between the transcription factors, or between them and the basal transcription machinery or a steroid receptor coactivator. |
| 2 | 10973497 | We show that DAF-16 and FKHR can interact with both the KIX and E1A/SRC interaction domains of p300/CBP, as well as the steroid receptor coactivator (SRC). |
| 3 | 11800161 | In what is a rapidly evolving area of research, findings to date have led to a proposed model of hormonal action, in which a receptor activated by estrogen or cell-membrane-derived phosphorylation-dependent signaling pathways promotes recruitment of selected members of the multifunctional steroid receptor coactivator family and the cointegrators, p300/CBP and P/CAF. |
| 4 | 20966046 | Here we showed that the DEAD-box RNA helicase p68 (DDX5) and its associated noncoding RNA, steroid receptor RNA activator (SRA), form a complex with CTCF that is essential for insulator function. p68 was detected at CTCF sites in the IGF2/H19 imprinted control region (ICR) as well as other genomic CTCF sites. |
| 5 | 20966046 | In vivo depletion of SRA or p68 reduced CTCF-mediated insulator activity at the IGF2/H19 ICR, increased levels of IGF2 expression, and increased interactions between the endodermal enhancer and IGF2 promoter. p68/SRA also interacts with members of the cohesin complex. |
| 6 | 20966046 | Depletion of either p68 or SRA does not affect CTCF binding to its genomic sites, but does reduce cohesin binding. |
| 7 | 21152033 | SRA in adipocytes increases both glucose uptake and phosphorylation of Akt and FOXO1 in response to insulin. |
| 8 | 21152033 | SRA promotes S-phase entry during mitotic clonal expansion, decreases expression of the cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1, and increases phosphorylation of Cdk1/Cdc2. |
| 9 | 21152033 | SRA also inhibits the expression of adipocyte-related inflammatory genes and TNF?-induced phosphorylation of c-Jun NH(2)-terminal kinase. |
| 10 | 19667111 | Pioglitazone downregulated SRA gene expression in adipose tissue of subjects with impaired glucose tolerance and decreased LOX-1 mRNA in vitro. |