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Gene Information

Gene symbol: SREBF2

Gene name: sterol regulatory element binding transcription factor 2

HGNC ID: 11290

Synonyms: SREBP2, bHLHd2

Related Genes

#	Gene Symbol	Number of hits
1	INS	1 hits
2	PPARGC1A	1 hits
3	PRKAA2	1 hits

Related Sentences

#	PMID	Sentence
1	14988395	In intact cells, SREBP-2 is phosphorylated by insulin, which seems to be related to their bio-responses on low density lipoprotein receptor activity.
2	14988395	These results suggest that activation of Erk-MAPK pathways by hormones such as insulin might be related to a novel regulatory principle of SREBP-2.
3	20440297	Ad-36 substantially increased Cidec/FSP27, ACC, sterol regulatory element-binding protein 1c (SREBP-1c), SREBP-2 and 3-hydroxy-3-methylglutaryl-CoA reductase protein abundance, but significantly reduced AMPK activity, mitochondrial mass and uncoupling protein 3 (UCP3) abundance in comparison with control cells (all P values are <0.01).
4	21109190	Here we demonstrate that in insulin-deficient diabetic mice, there is a reduction in expression of the major transcriptional regulator of cholesterol metabolism, SREBP-2, and its downstream genes in the hypothalamus and other areas of the brain, leading to a reduction in brain cholesterol synthesis and synaptosomal cholesterol content.
5	20111022	In visceral white adipose tissue, both MSG and HFCS diets increased the expression of transcription factor Srebf2 and decreased expression of Ppargc1a, while downregulating the expression of mitochondrial respiratory chain components.