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Gene Information
Gene symbol: SRF
Gene name: serum response factor (c-fos serum response element-binding transcription factor)
HGNC ID: 11291
Synonyms: MCM1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | MKL1 | 1 hits |
| 3 | MMP2 | 1 hits |
| 4 | MMP7 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20110336 | We found that insulin resistance and agonist stimulation increased the expression and activity of MMPs (MMP-2 and MMP-7), the EGFR, contractile proteins such as myosin light chain kinase and MLC II, and their transcriptional activators including P90 ribosomal kinase (P90RSK) and serum response factor, possibly via the activation of extracellular signal-regulated kinase (ERK1/2) in VSMCs. |
| 2 | 21393865 | Skeletal muscle from insulin-resistant mice recapitulated this gene expression pattern and showed reduced G-actin and increased nuclear localization of MKL1, each of which regulates SRF activity. |
| 3 | 21393865 | Pharmacological SRF inhibition by CCG-1423 reduced nuclear MKL1 and improved glucose uptake and tolerance in insulin-resistant mice in vivo. |