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Gene Information
Gene symbol: STAR
Gene name: steroidogenic acute regulatory protein
HGNC ID: 11359
Synonyms: StAR, STARD1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ABCG1 | 1 hits |
| 2 | CTNNB1 | 1 hits |
| 3 | CYP11A1 | 1 hits |
| 4 | CYP17A1 | 1 hits |
| 5 | SFRP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17211444 | Overexpression of a constitutively active mutant of beta-catenin induced the transcription of the StAR promoter (440%). beta-Catenin and FCCM induced SF-1-mediated transcription at a SF-1-driven reporter gene (420 and 402%, respectively). |
| 2 | 18481435 | Morphological changes of Leydig cells were observed by light microscopy (LM) and transmission electron microscopy (TEM), concentrations of serum luteinizing hormone (LH) and testosterone (T) were determined by enzyme linked immunosorbent assay (ELISA), and the mRNA levels in the steroidogenic acute regulatory protein (StAR), cytochrome P450 side chain cleavage (P450scc), cytochrome P450 17a-hydroxylase (P450c17), 17beta-hydroxysteroid dehydrogenase 3 (17beta-HSD3) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD1) from the Leydig cells were examined by RT-PCR. |
| 3 | 20826654 | LXR ligand treatment of streptozotocin-treated rats increases expression in the sciatic nerve of steroidogenic acute regulatory protein (a molecule involved in the transfer of cholesterol into mitochondria), of the enzyme P450scc (responsible for conversion of cholesterol into pregnenolone), of 5?-reductase (an enzyme involved in the generation of neuroactive steroids) and of classical LXR targets involved in cholesterol efflux, such as ABCA1 and ABCG1. |
| 4 | 21164259 | P450scc deficiency is the differential diagnosis of congenital lipoid adrenal hyperplasia caused by mutations in the steroidogenic acute regulatory protein, however, in contrast to the latter, these patients do not have adrenal hyperplasia but small adrenals and gonads. |
| 5 | 21915818 | Wnt antagonist sFRP-1 inhibited adipokine-mediated StAR activity, but did not affect ERK1/2 MAPK activation. |