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Gene Information
Gene symbol: STXBP3
Gene name: syntaxin binding protein 3
HGNC ID: 11446
Synonyms: UNC-18C
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | DOC2B | 1 hits |
| 2 | INS | 1 hits |
| 3 | SLC2A4 | 1 hits |
| 4 | SNAP23 | 1 hits |
| 5 | SNTG1 | 1 hits |
| 6 | STX4 | 1 hits |
| 7 | WNK1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11751846 | We examined the subcellular distribution of Munc18-c in response to acute (15-min) insulin (100 nm) stimulation after preincubation in 5 or 25 mm glucose +/- 0.6 nm insulin. |
| 2 | 11751846 | Under each condition except high glucose + insulin preincubation, acute insulin increased Munc18-c (50-200%) in TS-PM and decreased Munc18-c (60%) in TI-LDM. |
| 3 | 17548353 | The widely expressed Sec/Munc18 (SM) protein Munc18c is required for SNARE-mediated insulin granule exocytosis from islet beta cells and GLUT4 vesicle exocytosis in skeletal muscle and adipocytes. |
| 4 | 17548353 | Although Munc18c function is known to involve binding to the t-SNARE Syntaxin 4, a paucity of Munc18c-binding proteins has restricted elucidation of the mechanism by which it facilitates these exocytosis events. |
| 5 | 17548353 | Supporting the notion of Munc18c binding with Syntaxin 4 and Doc2beta in mutually exclusive complexes, in vitro competition with Syntaxin 4 effectively displaced Munc18c from binding to Doc2beta. |
| 6 | 17548353 | Taken together, these data support a model wherein Munc18c transiently switches from association with Syntaxin 4 to association with Doc2beta at the plasma membrane to facilitate exocytosis. |
| 7 | 17848561 | To search for WNK1 substrates related to exocytosis, we conducted a WNK1 two-hybrid screen, which yielded Munc18c. |
| 8 | 17848561 | Munc18c is known to be a key regulator of accessibility of the target membrane (t-SNARE) protein syntaxin 4 to participate in SNARE core complex assembly, although a paucity of Munc18c-binding factors has precluded discovery of its precise functions. |
| 9 | 19188424 | Protein interaction studies used subcellular fractions and detergent lysates prepared from MIN6 beta-cells to determine the mechanistic role of Munc18c in Syntaxin 4 activation and docking/fusion of vesicle-associated membrane protein (VAMP)2-containing insulin granules. |
| 10 | 19188424 | Munc18c depletion ablated the glucose-stimulated VAMP2-Syntaxin 4 association as well as Syntaxin 4 activation, correlating with the deficit in insulin release. |
| 11 | 18652694 | We investigated the effect of a 12 vs. 48 hr fast on insulin action and skeletal muscle Munc18c and Syntaxin 4 protein in lean and obese subjects. |
| 12 | 15331531 | Increases in Syn4 caused increases in Munc18c protein, indicating that Syn4 regulates Munc18c expression in vivo. |
| 13 | 15734838 | The disruption of Munc18c binding to syntaxin 4 impairs insulin-stimulated GLUT4 vesicle translocation in 3T3L1 adipocytes. |
| 14 | 16638745 | Tyrosine phosphorylation of Munc18c was also detected in 3T3L1 adipocytes and increased with insulin stimulation, suggesting that this may be a conserved mechanism. |
| 15 | 16638745 | Syntaxin 4 binding to Munc18c decreased as Munc18c phosphorylation levels increased in pervanadate-treated cells, suggesting that phosphorylation dissociates the Munc18c-Syntaxin 4 complex. |
| 16 | 16638745 | Mutagenesis of one residue in this region, Y219F, significantly increased the affinity of Munc18c for Syntaxin 4, whereas mutation of three other candidate sites was without effect. |
| 17 | 20460426 | Studies in L6 cells showed that Munc18c promoted the expression of SNAP23. |
| 18 | 20460426 | We also showed that Munc18c is a potential regulator of SNAP23. |