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Gene Information
Gene symbol: SUCLG2
Gene name: succinate-CoA ligase, GDP-forming, beta subunit
HGNC ID: 11450
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADCY7 | 1 hits |
| 2 | CTNNB1 | 1 hits |
| 3 | JUP | 1 hits |
| 4 | PDC | 1 hits |
| 5 | PITX2 | 1 hits |
| 6 | RGS7 | 1 hits |
| 7 | RGS7BP | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10812978 | The G beta 5 isoform exhibits novel properties in its activation of effector pathways such as MAPK, phospholipase C-beta, and adenylyl cyclase type II when compared to G beta 1. |
| 2 | 10812978 | Recently specific native complexes between G beta 5 and the regulator of G protein signaling (RGS) protein-7 (RGS7) and between G beta 5L (a splice variant with a 42 amino acid N-terminal extension) and RGS9 have been isolated from different retinal fractions. |
| 3 | 17647246 | Beta catenin, phosducin and aldehyde reductase were increased in expression in diabetes whilst succinyl coA ligase and dihydropyrimidase-related protein were decreased. |
| 4 | 17880698 | G beta 5 is the most structurally divergent G beta isoform and forms tight heterodimers with regulator of G protein signalling (RGS) proteins of the R7 subfamily (R7-RGS). |
| 5 | 17880698 | The subcellular localization of G beta 5/R7-RGS protein complexes is regulated by the palmitoylation status of the associated R7-binding protein (R7BP), a recently discovered SNARE-like protein. |
| 6 | 17880698 | Overexpression of wild-type R7BP, but not its palmitoylation-deficient mutant, greatly enriched the fraction of endogenous G beta 5/R7-RGS protein complexes in the lipid rafts. |
| 7 | 17880698 | In HEK-293 cells the palmitoylation status of R7BP also regulated the lipid raft targeting of co-expressed G beta 5/R7-RGS/R7BP proteins. |
| 8 | 17880698 | In cultured cells, the palmitoylation status of R7BP regulated the lipid raft targeting of endogenous or co-expressed G beta 5/R7-RGS proteins. |
| 9 | 17880698 | Taken together with recent evidence that the kinetic effects of the G beta 5 complex on GPCR signaling are greatly enhanced by R7BP palmitoylation through a membrane-anchoring mechanism, our data suggest the targeting of the G beta 5/R7-RGS/R7BP complex to lipid rafts in neurons and brain, where G proteins and their effectors are concentrated, may be central to the G protein regulatory function of the complex. |
| 10 | 20100282 | As the Disheveled, EGL-10, Pleckstrin homology domain is essential for R7BP binding to RGS7, we studied the subcellular localization of G beta(5) in primary neurons and brain from mice deficient in R7BP. |