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Gene Information
Gene symbol: SUCNR1
Gene name: succinate receptor 1
HGNC ID: 4542
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | MAPK1 | 1 hits |
| 2 | PTGS2 | 1 hits |
| 3 | REN | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19389848 | In summary, MD cells can sense alterations in local tissue metabolism via accumulation of tubular succinate and GPR91 signaling, which involves the activation of MAPKs, COX-2, and the release of prostaglandin E(2). |
| 2 | 19776718 | When the succinate receptor (SUCNR1) is activated in the afferent arterioles of the glomerulus it increases renin release and induces hypertension. |
| 3 | 20861827 | Also, the distal nephron-collecting duct system, which is the major source of (pro)renin in diabetes and has the highest level of GPR91 expression in the kidney, may have an important, active, and early role in the pathogenesis of DN in contrast to the existing glomerulus-centric paradigm. |