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Gene Information
Gene symbol: SUFU
Gene name: suppressor of fused homolog (Drosophila)
HGNC ID: 16466
Synonyms: SUFUH, SUFUXL, PRO1280
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GLIS3 | 1 hits |
| 2 | INS | 1 hits |
| 3 | PARK2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21543335 | We further showed that SUFU is able to inhibit the activation of the insulin promoter by Glis3 but not the activation by a Glis3 mutant deficient in its ability to bind SUFU, suggesting that the inhibitory effect is dependent on the interaction between the two proteins. |
| 2 | 21543335 | Exogenous SUFU did not affect the nuclear localization of Glis3; however, Glis3 promoted the nuclear accumulation of SUFU. |
| 3 | 21543335 | Additionally, we demonstrated that SUFU stabilizes Glis3 in part by antagonizing the Glis3 association with a Cullin 3-based E3 ubiquitin ligase that promotes the ubiquitination and degradation of Glis3. |
| 4 | 21543335 | This is the first reported instance of Glis3 interacting with SUFU and suggests a novel role for SUFU in the modulation of Glis3 signaling. |