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Gene Information
Gene symbol: SYT7
Gene name: synaptotagmin VII
HGNC ID: 11514
Synonyms: IPCA-7, SYT-VII, MGC150517
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | SENP1 | 1 hits |
| 3 | SUMO1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20978738 | In this study, we tested the relative contribution of dysregulated glucagon secretion and reduced insulin release in the development of hyperglycaemia and type 2 diabetes by using synaptotagmin-7 knockout (KO) mice, which exhibit glucose intolerance, reduced insulin secretion and nearly abolished Ca(2+)-stimulated glucagon secretion. |
| 2 | 21266332 | Granule localization was imaged by total internal reflection fluorescence and electron microscopy; immunoprecipitation and Western blotting were used to examine the soluble NSF attachment receptor (SNARE) complex formation and SUMO1 interaction with synaptotagmin VII. |
| 3 | 21266332 | SUMO1 coimmunoprecipitates with the Ca(2+) sensor synaptotagmin VII, and this is transiently lost upon glucose stimulation. |
| 4 | 21266332 | SENP1 overexpression also disrupts the association of SUMO1 with synaptotagmin VII and mimics the effect of glucose to enhance exocytosis. |