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Gene Information
Gene symbol: TBXAS1
Gene name: thromboxane A synthase 1 (platelet)
HGNC ID: 11609
Synonyms: CYP5, CYP5A1, THAS, TXS, TXAS, TS
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CYP17A1 | 1 hits |
| 2 | CYP1A1 | 1 hits |
| 3 | CYP2B6 | 1 hits |
| 4 | CYP2D6 | 1 hits |
| 5 | CYP3A4 | 1 hits |
| 6 | INS | 1 hits |
| 7 | KCNMA1 | 1 hits |
| 8 | NR1I2 | 1 hits |
| 9 | POR | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11259542 | The effect of glucagon and its second messenger cAMP on cytochrome P450 2C11 (CYP2C11) expression was investigated in primary hepatocytes cultured on Matrigel. |
| 2 | 12931254 | According to the results of pharmacokinetic studies, pitavastatin showed favorable and promising safety profile; it was only slightly metabolized by the cytochrome P450 (CYP) system, its lactone form had no inhibitory effects on the CYP3A4-mediated metabolism of concomitantly administered drugs; P-glycoprotein-mediated transport did not play a major role in its disposition, and pitavastatin did not inhibit P-glycoprotein activity. |
| 3 | 15242186 | In this paper, we present the effects of two organic fractions and two aqueous extracts from the leaves of S. sonchifolius on rat hepatocyte viability, on oxidative damage induced by tert-butyl hydroperoxide (t-BH) and allyl alcohol (AA), and on glucose metabolism and their insulin-like effect on the expression of cytochrome P450 (CYP) mRNA. |
| 4 | 17027963 | Collectively, these data suggest that bradykinin-induced, EDHF-dependent relaxation in small mesenteric arteries from db/db mice is mediated via cytochrome P450 product that activates the large conductance calcium-activated potassium (BK(Ca) or Slo) channel, whereas the acetylcholine-induced, EDHF-mediated relaxation involves neither cytochrome P450 product nor hydrogen peroxide. |
| 5 | 16972209 | For prevention, predisposing risk factors like electrolyte disturbances, pre-existing cardiac diseases, co-medication with QT prolonging drugs and medication with potential cytochrome P450 interaction have to be taken into consideration. |
| 6 | 19489075 | Streptozotocin-induced diabetes resulted in increased expression of drug metabolizing cytochrome P450s and also increased the clearance of the cytochrome P450 substrate zoxazolamine. |
| 7 | 20878594 | Evidence of cytochrome P450 (CYP)2D6 inhibition in clinical trials highlighted a concern for pharmacokinetic interaction with other drugs that are CYP2D6 substrates, as confirmed by a rise in the pharmacokinetic parameters of desipramine with concomitant administration of mirabegron. |
| 8 | 20410220 | Like all other microsomal cytochrome P450 (CYP) enzymes, CYP17A1 requires electron transfer from P450 oxidoreductase (POR). |
| 9 | 20300478 | In hepatic steatosis and steatohepatitis, the omega-oxidation cytochrome P450 CYP4A gene expression is increased even with reduced hepatic levels of PPARalpha. |
| 10 | 17591676 | Treatment of rats with DHEA influences expression of cytochrome P450 (P450) genes, including peroxisome proliferator-activated receptor alpha (PPAR alpha)- and pregnane X receptor (PXR)-mediated induction of CYP4As and CYP3A23, and suppression of CYP2C11. |