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Gene Information

Gene symbol: TCF7

Gene name: transcription factor 7 (T-cell specific, HMG-box)

HGNC ID: 11639

Synonyms: TCF-1

Related Genes

#	Gene Symbol	Number of hits
1	ABCC8	1 hits
2	HNF4A	1 hits
3	INS	1 hits
4	KCNJ11	1 hits
5	NR1H4	1 hits
6	PTPN6	1 hits
7	SLC10A1	1 hits
8	TCF7L2	1 hits

Related Sentences

#	PMID	Sentence
1	11279518	Tcf1-/- liver has decreased expression of the basolateral membrane bile acid transporters Slc10a1, Slc21a3 and Slc21a5, leading to impaired portal bile acid uptake and elevated plasma bile acid concentrations.
2	11279518	The Tcf1 protein (also known as HNF-1alpha) also regulates transcription of the gene (Nr1h4) encoding the farnesoid X receptor-1 (Fxr-1), thereby leading to reduced expression of small heterodimer partner-1 (Shp-1) and repression of Cyp7a1, the rate-limiting enzyme in the classic bile acid biosynthesis pathway.
3	12675668	The I27L polymorphism of TCF1 is an independent determinant of beta-cell function by affecting both 1st and 2nd phase insulin response.
4	16873704	We examined the association of variants in genes encoding several transcription factors (TCF1, TCF2, HNF4A, ISL1, IPF1, NEUROG3, PAX6, NKX2-2, NKX6-1, and NEUROD1) and genes encoding the ATP-sensitive K(+) channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) with type 2 diabetes in a Japanese cohort of 2,834 subjects.
5	17828387	Heterozygous mutations of glucokinase (GCK) and hepatocyte nuclear factor-1 alpha (HNF1A; also known as hepatic transcription factor 1 [TCF1]) genes are the most common cause of MODY.
6	19885641	We examined the association of rs7903146 variant in the transcription factor 7 like 2 gene (TCF7L2) with T2DM in 333 Palestinian subjects (219 were type 2 diabetic patients and 114 normoglycemic subjects).