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Gene Information
Gene symbol: TFAM
Gene name: transcription factor A, mitochondrial
HGNC ID: 11741
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATIC | 1 hits |
| 2 | FOXC2 | 1 hits |
| 3 | IHG1 | 1 hits |
| 4 | INS | 1 hits |
| 5 | PDHX | 1 hits |
| 6 | PDX1 | 1 hits |
| 7 | PPARA | 1 hits |
| 8 | PPARG | 1 hits |
| 9 | PPARGC1A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10603304 | The expression of both mtDNA (by mtTFA) and nDNA for oxphos and UCP (by NRFs, etc.) is coordinated by a factor called PGC-1. |
| 2 | 15151993 | In conclusion, loss of PDX1 function alters expression of mitochondrially encoded genes through regulation of TFAM leading to impaired insulin secretion. |
| 3 | 16380484 | In addition, metformin and AICAR increased the mRNA expression of nuclear respiratory factor-1 and mitochondrial DNA transcription factor A (mtTFA) and stimulated the mitochondrial proliferation. |
| 4 | 16631115 | Peroxisome proliferation-activated receptor-gamma (PPAR-gamma) coactivator-1 alpha (PGC-1alpha) increases mitochondrial transcription factor A (Tfam) resulting in mitochondrial DNA content increase. |
| 5 | 16631115 | The PGC-1alpha protein bearing glycine had impaired coactivator activity on Tfam promoter-mediated luciferase. |
| 6 | 16631115 | These results suggest that PGC-1alpha variants with Gly/Gly at 482nd amino acid may impair the Tfam transcription, a regulatory function of mitochondrial biogenesis, resulting in dysfunctional mtDNA replication. |
| 7 | 19656489 | Thus, the genetic control by the beta cell-specific factor Pdx1 of the ubiquitous gene TFAM maintains beta cell mtDNA vital for ATP production and normal GSIS. |
| 8 | 19576748 | HT over the concentration range of 0.1-10 micromol/L stimulated the promoter transcriptional activation and protein expression of peroxisome proliferator-activated receptor (PPAR) coactivator 1 alpha (PPARGC1 alpha, the central factor for mitochondrial biogenesis) and its downstream targets; these included nuclear respiration factors 1 and 2 and mitochondrial transcription factor A, which leads to an increase in mitochondrial DNA (mtDNA) and in the number of mitochondria. |
| 9 | 21270254 | Among tested forkhead genes, Foxc2 is unique in its ability to trans-activate the nuclear-encoded mitochondrial transcription factor A (mtTFA/Tfam) gene--a master regulator of mitochondrial biogenesis. |
| 10 | 21784897 | Conversely, inhibition of IHG-1 expression decreased mitochondrial mass, downregulated mitochondrial proteins, and PGC-1?-regulated transcription factors, including nuclear respiratory factor 1 and mitochondrial transcription factor A (TFAM), and reduced activity of the TFAM promoter. |