Ignet

Gene Information

Gene symbol: THBS1

Gene name: thrombospondin 1

HGNC ID: 11785

Synonyms: TSP1, THBS, TSP, THBS-1, TSP-1

Related Genes

#	Gene Symbol	Number of hits
1	ADIPOQ	1 hits
2	AGT	1 hits
3	AGTR1	1 hits
4	AHR	1 hits
5	CD47	1 hits
6	COL1A1	1 hits
7	CREB5	1 hits
8	EBF1	1 hits
9	F2	1 hits
10	IGF1	1 hits
11	INS	1 hits
12	NFAT5	1 hits
13	SERPINF1	1 hits
14	SGCB	1 hits
15	SORBS1	1 hits
16	TGFB1	1 hits
17	USF2	1 hits
18	VEGFA	1 hits
19	VWF	1 hits

Related Sentences

#	PMID	Sentence
1	1353387	TSP was partially colocalised with the endothelial cell marker, von Willebrand factor, in PDR.
2	16310163	In this paper, we examined whether Ang II similarly upregulates TSP1 production and TSP1-dependent TGF-beta activation alone or in combination with high glucose concentrations.
3	16310163	Ang II and high glucose stimulated increases in TSP1 protein levels in the conditioned media of both rat cardiac fibroblasts (RCFs) and rat mesangial cells (RMCs).
4	16310163	Moreover, Ang II induction of TSP1 and increased TGF-beta activity were blocked by losartan, an antagonist of the Ang II type 1 (AT1) receptor.
5	16310163	The increase in TSP1 expression leads to increased TGF-beta activity upon Ang II and/or glucose treatment, since peptide antagonists of TSP1-mediated TGF-beta activation blocked Ang II and glucose-induced TGF-beta activation.
6	16630453	After hemodynamic measurements by the end of the study, myocardial collagen content was quantified in Masson-stained samples and the mRNA expressions of TSP-1 and TGFbeta(1) were detected by quantification real-time RT-PCR.
7	16873687	In the matrigel, proangiogenic VEGF expression was decreased, while antiangiogenic thrombospondin-1 was upregulated in diabetic mice, regardless of the presence of RAGE.
8	16767790	Coimmunoprecipitation and radioligand competitive-binding assays confirmed the direct interactions between adiponectin and alpha2M, or TSP-1.
9	17881461	Our previous studies demonstrated that the transcription factor, upstream stimulatory factor 2 (USF2), was upregulated by high glucose, which bound to an 18-bp sequence in the thrombospondin 1 (TSP1) gene promoter and regulated high glucose-induced TSP1 expression and TGF-beta activity in mesangial cells, suggesting that USF2 might play a role in the development of diabetic nephropathy.
10	19397838	In response to high glucose, several of these transcription factors regulate the gene encoding the profibrotic cytokine transforming growth factor beta, as well as genes for a range of other proteins implicated in inflammation and extracellular matrix turnover, including thrombospondin 1, the chemokine CCL2, osteopontin, fibronectin, decorin, plasminogen activator inhibitor 1 and aldose reductase.
11	19689798	Transcription factors PPARgamma, NFAT5, CREB5 and EBF1, the adipokine NAMPT, members of the insulin signaling cascade SORBS1 and IGF1 and IL6ST were repressed, while the adipokine THBS1 and GLUT4 involved in insulin signaling were induced.
12	20689700	The addition of TSP-1 to primary SMC was sufficient to enhance IGF-I responsiveness in normal glucose.
13	19365032	We consistently observed lower levels of TSP-1 in diabetic patients who expressed the higher-molecular-weight PEDF isoform.
14	19365032	Although the PEDF level did not change, the diabetic samples with the higher-molecular-weight PEDF isoform consistently showed lower levels of TSP-1.
15	12644443	The TSP-1 antagonist LSKL peptide reduced bioactive TGF-beta and fibronectin, indicating the dependence of TGF-beta1 activation on TSP-1.
16	20164378	It is well established that thrombospondin1 (TSP1) is a major regulator of TGF-beta activation in renal and cardiac complications of diabetes.
17	20164378	Together, these data establish that glucose-mediated downregulation of PKG levels stimulates TSP1 expression and enhances TGF-beta activity and matrix protein expression, which can contribute to vascular remodeling in diabetes.
18	16816123	For example, levels of proangiogenic VEGF-A, VEGF-B, neuropilin-1, VEGFR-1, and VEGFR-2 were reduced and the levels of antiangiogenic thrombospondin-1 and retinoblastoma like-2 were increased.
19	20233213	We have shown that the secreted matrix protein thrombospondin-1 (TSP-1) binds to CD47 and potently inhibits NO stimulation of sGC in endothelial and vascular smooth muscle cells (VSMCs) and platelets.
20	20233213	Here we show that TSP-1 signalling via CD47 inhibits sGC activation by NO-independent sGC activating small molecules.
21	20233213	TSP-1 pretreatment also inhibited the ability of these agents to delay thrombin-induced platelet aggregation.
22	18515748	The constitutively active form of AhR induced activation of the thrombospondin-1 gene promoter.