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Gene Information
Gene symbol: TLR2
Gene name: toll-like receptor 2
HGNC ID: 11848
Synonyms: TIL4, CD282
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATF4 | 1 hits |
| 2 | CCL2 | 1 hits |
| 3 | CXCL1 | 1 hits |
| 4 | HMGB1 | 1 hits |
| 5 | HSPD1 | 1 hits |
| 6 | ICAM1 | 1 hits |
| 7 | IL1B | 1 hits |
| 8 | IL6 | 1 hits |
| 9 | IL8 | 1 hits |
| 10 | INS | 1 hits |
| 11 | IRS1 | 1 hits |
| 12 | MYD88 | 1 hits |
| 13 | NFKB1 | 1 hits |
| 14 | PRKCD | 1 hits |
| 15 | TLR4 | 1 hits |
| 16 | TLR5 | 1 hits |
| 17 | TLR6 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18787058 | The aims of the present study were to investigate the expression of toll-like receptor 2 (TLR2) in muscle and white adipose tissue (WAT) of diet-induced obesity (DIO) mice, and also the effects of its inhibition, with the use of TLR2 antisense oligonucleotide (ASON), on insulin sensitivity and signaling. |
| 2 | 18787058 | In addition, data show that the inhibition of TLR2 expression prevents the activation of IKBKB, MAPK8, and serine phosphorylation of IRS1 in DIO mice, suggesting that TLR2 is a key modulator of the crosstalk between inflammatory and metabolic pathways. |
| 3 | 19447045 | Down-regulation of TLR2 and TLR4 abrogates HG-induced IP-10 release via NF-kappaB inhibition. |
| 4 | 20407745 | Bone-marrow-derived dendritic cells and pancreatic islets from Tlr2(-/-) mice did not increase IL-1beta expression in response to a NEFA mixture, whereas Tlr2(+/+) control tissues did. |
| 5 | 20733560 | Wounds of TLR2(-/-)+STZ mice showed less oxidative stress, decreased MyD88 signaling, NF-?B activation, and cytokine secretion. |
| 6 | 20933500 | Overexpression and knockdown experiments showed the importance of activating transcription factor 4 (ATF4), an ER stress-induced transcription factor, in the induction of TLR2 expression during ER stress. |
| 7 | 20933500 | This was confirmed by the increased expression and function of TLR2 during treatment with salubrinal, an activator of ATF4 pathway. |
| 8 | 21103982 | However, deletion of Prkcd destabilised mRNA transcripts for Nos2, and for multiple components of the toll-like receptor 2 (TLR2) signalling complex, which resulted in disrupted TLR2 signalling. |
| 9 | 20959532 | In THP-1 cells, palmitate increased cellular TLR2 and TLR4 expression, generated reactive oxygen species (ROS), and increased NF-?B activity, IL-1?, and MCP-1 release in a dose- and time-dependent manner. |
| 10 | 20959532 | Moreover, data from transient transfection experiments suggest that TLR6 is required for TLR2 and MD2 for TLR4 to augment inflammation in FFA- and glucose-exposed cells. |
| 11 | 21162749 | Stimulation of TLR2 or TLR4 induced NF-?B activation, and the expression of ICAM-1, IL-6 and IL-8. |
| 12 | 20067962 | Ligands of TLR2 and TLR4, namely, HSP60, HSP70, HMGB1, endotoxin, and hyaluronan levels, were elevated in type 2 diabetic subjects and positively correlated with TLR2 and TLR4. |
| 13 | 19348674 | Both peptidoglycan and lipopolysaccharide (LPS) robustly induce TLR2 mRNA expression, whereas TLR4 mRNA is weakly induced by LPS only (P < 0.05). |
| 14 | 21503675 | Gene knockdown of TLR4 prevented palmitate-induced INS-1 cell death, while knockdown of TLR2 did not. |
| 15 | 21813778 | Early aggregates of hIAPP, but not nonamyloidogenic rodent islet amyloid polypeptide, caused release of CCL2 and CXCL1 by islets and induced secretion of TNF-?, IL-1?, IL-1?, CCL2, CCL3, CXCL1, CXCL2, and CXCL10 by C57BL/6 bone marrow-derived macrophages. hIAPP-induced TNF-? secretion was markedly diminished in MyD88-, but not TLR2- or TLR4-deficient macrophages, and in cells treated with the IL-1R antagonist (IL-1Ra) anakinra. |
| 16 | 20809521 | Our results show that islet graft failure can be initiated by TLR2 and TLR4 signaling and suggest that HMGB1 is one likely early mediator. |
| 17 | 20956025 | Taken together, the experimental data suggests Toll like receptor 2 (TLR-2) plays a dominant role in CTB mediated INS inhibition of DC induced type 1 diabetes onset in human Type 1 diabetes autoimmunity. |
| 18 | 21985371 | We have found that the expression of TLR5 is up-regulated by glucose activation of isolated islets of Langerhans, in contrast to other investigated TLRs (TLR-2, -3, -4, -6 and -9. |